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Articles by Ali Shamsizadeh
Total Records ( 3 ) for Ali Shamsizadeh
  Gholamreza Sepehri , Vahid Sheibani , Afrooz Azarang , Ali Shamsizadeh , Mohammad Reza Afarinesh , Saeed Azizollahi and Ehsan Sepehri
  Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy in a single dose (5 mg kg-1). For chronic experimental protocol, Morphine was administered daily (15 mg kg-1 for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. In acute and chronic experiments, W-7 (0.25, 0.5 and 1 μmol/rat) was injected through ICV at different paradigms. Maximal Possible Effect percentage (MPE%) was considered as analgesia index. Results: Our result showed that W-7 (0.25, 0.5 and 1 μmol/rat) injections before acute morphine administration significantly reduced the analgesic effect of morphine compared with morphine treated group (all p<0.05). Chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 μmol/rat) decreased the development of tolerance to it. Conclusion: In conclusion these data showed that acute administration of W-7 reduced the analgesics effect of morphine and chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.
  Gholamreza Sepehri , Kayvan Yaghoobi , Vahid Sheibani , Ali Shamsizadeh and Mohammad Khaksari
  Problem statement: This study was performed to evaluate the effect of W7 (specific calmodulin inhibitor) on morphine induced analgesia in Adrenalectomized (ADX) rats by tail-flick test. Approach: Tolerance to morphine was induced in male Wistar rats by daily injections of morphine (15 mg kg-1, i.p) for 8 days. Adrenalectomy was performed under general anesthesia with intraperitoneal (i.p) injection of ketamine (50 mg kg-1) and xylazine (5 mg kg-1). In sham operated animals only the incision was made but adrenals were not removed. Five days after surgery, W7 (0.25, 0.5, 1 and 2 μmol rat-1) was injected Intracerebroventricularlly (ICV) concomitant with morphine (15 mg kg-1, i.p) for 8 consecutive days. Tail Flick Latency (TFL) was used to assess the nociceptive response at days 1, 3, 5 and 8 before and 30 min after morphine administration in sham operated and ADX rats. Maximal Possible Effect percentage (MPE %) was considered as analgesia index. Results: The results showed that daily morphine injection caused a marked analgesia in rats, but MPE % decreased significantly after 8 days which shows the development of tolerance to morphine (p<0.05). MPE % following morphine treatment in ADX rats was significantly greater than sham operated rats (p<0.05) and W7 (0.5, 1 and 2 micromol/rat/ICV) significantly attenuated the development of tolerance to morphine in ADX rats compared to sham operated rats (p<0.05 and p<0.001). Corticosterone replacement reversed the effect of W7 on ADX rats (p<0.005). Conclusion: The results of this study showed that hypothalamic- pituitary-adrenal axis and calmodulin may play a role in the development of tolerance to morphine antinociceptive effects in rats.
  Reza Nosratabadi , M.K. Arababadi , G. Hassanshahi , N. Yaghini , V. Pooladvand , Ali Shamsizadeh , E.R. Zarandi and H. Hakimi
  The present study was aimed to examine the serum level of IFN-γ in type 2 diabetic patients with nephropatic complications. In this experimental study, serum samples were obtained from 100 type 2 diabetic patients suffering from nephropathy and 100 healthy controls. Serum level of IFN-γ was analyzed by ELISA. Results of this study showed that the mean serum level of IFN-γ was 16.09±2.04 and 4.03±1.00 pg mL-1 in nephropathic patients and healthy controls, respectively. Statistical analysis of data showed that the difference in the IFN-γ serum level was significant between nephropathic patients and controls. Due to the elevated level of IFN-γ in nephropathic patients, it can be possibly concluded that IFN-γ is involved in nephropathy complication of type 2 diabetes.
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