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Articles by Ali Rezaie
Total Records ( 10 ) for Ali Rezaie
  Ali Rezaie
  Not available.
  Mohammad Rahbani , Daryoush Mohajeri , Ali Rezaie and Mehrdad Nazeri
  The negative impact of diabetes on the retinal, renal, nervous and cardiovascular systems is well recognized yet little is known about the effect of this disease on the liver. Oxidative stress is currently suggested as a mechanism underlying diabetes mellitus complications. The present study was designed to assess the liver injury as a complication of diabetes mellitus and to evaluate the hepaoprotective properties of ethanolic extract of Saffron (dried stigmas of Crocus sativus L.) in streptozotocin-induced diabetes in rats. Aminotransferases, Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were measured to determine the concentration of intracellular hepatic enzymes that have leaked into the circulation and serve as a marker of hepatocyte injury. Alkaline Phosphatase (ALP) and bilirubin were measured to assess biliary function. Albumin was measured to reflect liver synthetic function. The lipid peroxidation product, Malondialdehyde (MDA) and reduced Glutathione (GSH) content was measured to assess free radical activity in the liver tissues. The enzymatic activities of Glutathione Peroxidase (GSH-Px), Superoxide Dismutase (SOD) and Catalase (CAT) were measured as indicators of antioxidation in liver tissue. Moreover, histopathological observations were assayed at the degree of hepatic injury. For this purpose, male Wistar rats were made diabetic with a single injection of STZ (75 mg kg-1 i.p.). Rats were randomly separated into four groups, each containing 10 animals: Group 1, healthy control rats; Group 2 non-diabetic rats were treated with 40 mg kg-1 b.w./day intraperitoneal (i.p.) injection of Saffron extract; Group 3, diabetic rats; Group 4, diabetic rats were treated with saffron extract (40 mg kg-1 b.w./day, i.p.) for a period of 8 weeks. At the end of the experiment, MDA contents of the liver tissue and serum levels of ALT, AST, AP and bilirubin in Groups 3 were found to be significantly increased as compared to Group 1 (p<0.05) and these serum biomarkers of hepatic injury and liver MDA level in Group 4 were significantly decreased as compared to Group 3 (p<0.05). The GSH, SOD, CAT and GSH-Px contents of the liver and serum albumin level in Group 3 was significantly decreased as compared to Group 1 (p<0.05) and were found to be significantly increased in Group 4 as compared to Groups 3 (p<0.05). Histopathological changes were in agreement with biochemical findings. Based on these findings, it is presumed that ethanolic extract of C. sativus L. stigma may have the hepatoprotective effect in experimentally induced diabetic rats. Researchers suggest that saffron extract has beneficial effects on antioxidant defence of diabetic liver tissue.
  Ali Rezaie , Arash Pezeshki , Behzad Zadfattah , Mehrdad Nazeri , Changiz Ahmadizadeh and Babak Mohammadi
  Celandine with scientific name Chelidounium majus, spreads across the world and exists in Northern parts of Iran like Gilaan, the outskirts of Rasht, Roodbar and Mazandaran. Some of effective chemical compounds are: malic, copticine, cityicacid, chelerythrine, berberine, succinic acid and sangainarine acid. The herb’s other medical properties are: calmative, narcotic, anti spasm, lowering blood pressure, antibilious, cathartic and wormroot in internal uses. Epispastics and flesh wound amneliorator in external uses. Other chemical compounds of the herb have alkaloids that some of which are toxic those alkaloids are Chelidtine hemochelidotine, cheleritrine, sangainarine and protopine. In the present study, 30 Wistar male rats of 200-230 g weight and about 3 months old were used for laboratory experiments. Animals were kept in standard condition, at 20-25°C, 70% humidity and light cycle of 12 h lighting and 12 h darkness. Standard plates were used in order to feeding by method of ad-libitum, i.e., 24 h feeding. It can be concluded, generally that based on different studies the extract of celandine may affect via effecting on benzodiazepine receivers connected to GABA receivers (considering its flavonoid content). Based on the obtained results by the present study it can be said that according to sedation process the extract dosage of 400 mg kg-1 BW among other dosages has had more meaningful results and has a better sedation, pre-anesthetic and anti-anxiety effects compared with diazepam (p<0.01).
  Ali Rezaie , Arash Pezeshki , Behzad Zadfattah , Mehrdad Nazeri , Changiz Ahmadizadeh and Babak Mohammadi
  Hempseed with scientific name Cannabis sativa, spreads across the world. Hempseed oil’s fatty acids compounds were obtained from different parts of Iran with different weather and were tested. The herb contains canabidole, canabinol and canabidiolic acid. The herb is used for preparing some sedation drugs which are used in neural stresses, anxiety, migraine, asthmatic coughs as well as local anesthesia in dentistry. Stuart points out that all parts of hempseed are used in China traditional medicine. Its seed is used as tonic, strengthening, laxative, diuretic, calmative, gastric anti parasite and narcotic. Masson and Teobold say that hempseed has a great value for tetanus treatment. Hempseed is a real calmative for stomachache and digestive disorders as well as beneficial for cancers, ulcers and rheumatic pains. In the present study, 30 Wistar male rats of 200-230 g weight and about 3 months old were used for laboratory experiments. Animals were kept in standard condition, at 20-25°C, 70% humidity and light cycle of 12 h lighting and 12 h darkness. Standard plates were used in order to feeding by method of ad libitum, i.e., 24 h feeding. Especial dishes were used for water. The rats were numbered in groups consisted of 5 animals and were placed in especial cages.
  Ali Rezaie , Amirreza Ebadi , Mehrdad Nazeri , Samad Rezaie and Fatemeh Elmi
  Aloe vera is a perennial succulent belong to the Lily (Liliaceae) family. This plant has been known as the healing plant. Aloe vera has been used for traditional medical purposes in several cultures for millennia. It has been demonstrated that Aloe vera has growth promoting activities. The objective of this study was to determination of the effect of Aloe vera on healing of the experimental skin wounds on rats and its comparison with zinc oxide. Zinc oxide is being used worldwide as an absorbent and protective compound. Its pharmacological properties are wide and its non-toxic material allows it to be used as a routine skin care substance. In current study, 70 female wistar rats where included in 5 groups. Full thickness incisional wound with 23 mm diameter was made with surgical scissors and scalpel. The whole operation was taking place under general anesthesia and analgesia circumstances. After making surgical wounds, rats are treated as mentioned in the text. Rats are observed for 21 days for wound closure process and inflammatory conditions taking place in wound. Biopsy intervals are 0 (the day of surgery), 3, 7, 14 and 21th day after surgery. In these certain days rats were euthanized and biopsies of wound sites were obtained. Wounds areas are also, measured by Scion Image ™ Software daily. At last, all data were analyzed using SPSS Statistics Ver.17. As a result, Aloe vera at the dose of 10% has significant healing properties compared to Zinc oxide. These data were validating under confidence surface of 95% (p<0.01).
  Ramin Shishehgar , Ali Rezaie and Mehrdad Nazeri
  Humulus lupulus (hops) is a climbing perennial vine that vigorously grows 20-35 feet each year. Humulus lupulus is a member of the hemp family which has grown wild since ancient times in Europe, Asia and North America. The female flowers mature in late Summer and are used to add bitterness, flavor and aroma to beer. In ancient times the young shoots were eaten as a vegetable and the dried flowers were used for their slight narcotic effect and sedative action in the treatment of mania, toothache, earache and neuralgia. One modern herbal medicine practitioners continue to use hops as a sedative and mild hypnotic as well as for its endocrine, free radical scavenging and antitumor properties. The aim of this study was to investigation of the sedation, pre-anesthetic and anti-anxiety effects of hop (Humulus lupulus L.) extract compared with diazepam in rats. In the present study 30 wistar male rats weighting 300±10 g and about 3 months old were used for laboratory experiments. In order to evaluate the sedation and pre-anesthetic effects of hop extract compared with diazepam, 50 mg kg-1 of extract in 1st group, 100 mg kg-1 in 2nd group, 1.2 mg kg-1 in 3rd group, 2 mg kg-1 in Group 4th, 2 mg kg-1 amount of dimethyl sulfoxide was injected intra peritoneal in 5th group and 6th group did not receive any drug. Data showed that hop extract has better sedation, pre-anesthetic and anti-anxiety effects than diazepam. Researchers suggest that still need more studies on this plant component in order to understand the more sedative and anxiolytic effects of this plant.
  Karim Amininia , Amirparviz Rezaeisaber and Ali Rezaie
  Copper deficiency in ruminants occurs either as a primary or as a secondary deficiency. Most of the copper deficiencies in livestock which occur naturally are conditioned by the presence of dietary factors that interfere with the absorption or utilization of copper by the animal. The main subjective of this study was to evaluation of effect of climatic factors on copper and its antagonist contents in the soil. In this study, during the seasons, researchers aimed to recording the rainfall, environmental temperature, soil temperature and humanity. In this study, researchers collected about 72 soil samples (18 samples in each season) from different areas of Ahar city, East Azerbaijan province of Iran. Then, samples were sent to the laboratory and the trace elements content of soil samples was measured by atomic absorption method. Results showed that Cu, Zn, Fe, Ca, S, Co and Mo was 20.36, 7.3, 43.73, 173.26, 596, 10.69 and 16.12, respectively. In conclusion can be conclude that present study is unique because there was no documented literatures about cu and its antagonist content in the soil of East Azerbaijan area. So, researchers suggests that there is more study needs to conclude about this matter.
  Ali Rezaie , Babak Lotfollahi , Daryoush Mohajeri , Ghafour Mousavi , Mehrdad Nazeri , Solmaz Zakhireh and Babak Mohammadi
  Acceleration in healing of surgical skin wounds, in order to reduction of post-operation consequences is most important. One of the most popular compounds used ever for skin care is lavender oil or Lavandula stoechas essential oil. The aim of this study was evaluate the healing effects of Lavandula stoechas extract in comparison with zinc oxide ointment on full thickness experimental open surgical skin wound healing in the rats. For this purpose, 75 female Wistar rats were randomly assigned in 5 groups of 15 animals each including: Control, treated by Eucerin as the placebo, treated by zinc oxide topical ointment and two remaining as test groups which received 10 and 20% Lavandula stoechas extracts. Under the general anesthesia and analgesia circumstances, a full thickness incisional open wound with 23 mm diameter was made on the skin of the back part of the rats. The healing process was studied macroscopically and microscopically at 0 (the day of surgery) 3, 7, 14, 21 and 28th days of experiment in all of the rats. The greatest degree of wound contraction was considered in Lavandula stoechas extract (10%) treated rats while this change was slighter in control group. In microscopic examination, the overall healing process of Lavandula stoechas extract (10%) treated rats was significantly better than the other experimental groups (p<0.05). The results obtained showed that Lavandula stoechas extract (10%) has more effective healing properties on full thickness open skin wounds compared to zinc oxide topical ointment.
  Amir Reza Ebadi , Ali Rezaie , Mehrdad Nazeri and Behboud Jafari
  Allium genus has some valuable species such as onion and garlic for human being. Allium jesdianum Bois species is a bulbar and durable plant with 2-3 leaves which grows in altitudes of Arasbaran region. The herb has various uses in foods and is used traditionally in treatment and decreasing rheumatic and digestive pains as well as renal calculus excrete. The aim of this study was to evaluating the anti bacterial effects of Allium jesdianum Boiss extract. Microorganisms were cultured in agar mauler Hilton media such that swabs smeared with bacterial suspension were moved traversal on the media surface then the media was turned at angle of 60° and culturing were repeated 2 times. These results demonstrated that sulfide compounds form an important part of extract’s constituents. Also, curzerenon and curzernne are the materials which are available significantly in this extract. Anti microbial effects of understudied herb are probably due to presence of sulfide and trepnoid compounds.
  Ali Rezaie , Behboud Jafari , Ghafour Mousavi , Mehrdad Nazeri , Amirreza Ebadi , Changiz Ahmadeh and Elmira Habibi
  In the present study, sedative and anti-anxiety drugs such as chemical drugs are used for the sedation and anti-anxiety but due to their side effects and economical issues, the significance of research on finding sedative and anti-anxiety drugs with less side effects and their ability to substitute these synthetic drugs and substituting newer sedation and anti-anxiety compounds is obvious. Origanum majorana is one of the plants that have the effect sedation and anti-anxiety. The aim of this research was to examine the effects of sedative, pre-anesthetic and anti-anxiety of Origanum majorana with diazepam in rats to different groups of male Wistar rats received herbal extract Origanum majorana with doses (100, 200, 400 mg kg-1, IP) and diazepam with dose of (1/2 mg kg-1, IP) and dimethyl sulfoxide with the equal volume. About 30 min after assessing the relift/sleep inducing effect (induced sleep duration by ketamine 40 mg kg-1, IP) anti-anxiety effects (using elevated plus maze). The results show meaningful increase in the period of the sleep that had been made with ketamine and also meaningful increase in the spend time at open arms in the patient group with the previous. The results show that the dose of extract Origanum majorana 200 mg kg-1 relieving effects of sedative, pre-anesthetic and anti-anxiety and before.
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