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Articles by Ali RAMAZANI
Total Records ( 4 ) for Ali RAMAZANI
  Neda Adibpour , Saeed Rezaee , Ali Khalaj , Ali Ramazani and Fakher Rahim
  In silico biology, including computers, databases, methods and algorithms are used for statistically analyzing the data to achieve the extract information and to identify the relationships between these data sets. This study aimed to provide alternative and new drugs that connect to DNA by using in vivo, in silico and find the best option from the newly designed series of drugs. Out of 143 DNA dodecamer crystal structures available in PDB, we have selected three structures and retrieved from the Protein Data Bank (PDB), with minor/major groove or both groove biding mode. Eighteen experimental ligands were docked using AutoDock 4.3 program into the active sites of selected drug-DNA structures. We docked our experimental ligands into three modeled DNA structured and compared those to internal evaluated ligands (drug compounds include ditercalinium, adriamycin and propamidine) and observed the same binding sites in experimental ligands in comparison to internal ligands. Docking results of 6m and 6p compounds into oligonucleotide in comparison to adrimycin and propamidine showed almost same binding fashion. Our results display that the most plausible mode of action of these experimental drugs as DNA binding agents is through intercalation of AT base pairs-linker chain and azole-minor groove. Accordingly, other DNA-drug crystal structures can be used as good patterns for further improvements using in silico and structure-based drug design methods.
  Ahmad Morsali , Hassan Hosseni Monfared , Ali Ramazani , Nader Noshiranzadeh , Ali Morsali and Matthias Zeller
  Two new MnII and FeII complexes with 4'-(4-pyridyl)-2,2' : 6',2''-terpyridine (pyterpy), [Mn(pyterpy)(MeOH)2(OAc)](ClO4) (1) and [Fe(pyterpy)2](SCN)2 · MeOH (2) have been synthesized and characterized by CHN elemental analysis, IR spectroscopy, and structurally analyzed by single-crystal X-ray diffraction. The thermal stabilities of these compounds were studied by thermal gravimetric (TG) and differential thermal analyses (DTA). The potentially tetradentate pyterpy ligand is a tridentate donor to both Mn(II) and Fe(II). The non-coordinated pyridyl interacts via O-H ··· N and C-H ··· N hydrogen bonds with adjacent molecules in 1 and 2, respectively, to form inversion symmetric dimers. Compound 1 is further extended into infinite hydrogen bonded chains via pairs of O-H ··· Oacetate hydrogen bonds.
  The 1:1 iminium intermediate generated by the addition of a secondary amine to aromatic bis-aldehydes (isophthalaldehyde and terphthalaldehyde) is trapped by the N-isocyaniminotriphenylphosphorane in the presence of a aromatic carboxylic acid derivative, which leads to the formation of corresponding iminophosphorane intermediate. Then disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediates. The reactions were completed in neutral conditions at room temperature and the corresponding disubstituted 1,3,4-oxadiazole derivatives were produced in excellent yields.
  Mohsen VALIZADEH HOLAGH , Abel Mohammadali oglu MAHARRAMOV , Mirza Aliakbar oglu ALLAHVERDIYEV , Ali RAMAZANI , Yavar AHMADI and Ali SOULDOZI
  Reactions of N-isocyaniminotriphenylphosphorane with cyclobutanone in the presence of aromatic (or heteroaromatic) carboxylic acids proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1-(5-aryl-1,3,4-oxadiazol-2-yl)- 1-cyclobutanol derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed. The structures of the products were deduced from their IR, 1HNMR, and 13CNMR spectra, and mass spectrometry.
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