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Articles by Ali Mirzaei
Total Records ( 2 ) for Ali Mirzaei
  Ali Mirzaei and Noshin Mirzaei
  Oak (Quercus sp.,) fruit has external and internal layers and the internal layer of the fruit is known as Jaft in some parts of Iran. Acute toxicity (LD50) was estimated by the intraperitoneal (i.p.) and oral (p.o.) routes. For the sub-chronic study, 20 adult Wistar rats were randomly divided into 4 groups (1-4) comprised of 5 animals each. Animals received Jaft extract daily by gavage at doses of 250, 500 and 1000 mg kg-1 for 28 days. At the end of the experiment, blood was collected for hematology and biochemical tests. For histopathological study, liver was dissected and prepared slides with 4-6 mm thick. LD50 of the Jaft extract in p.o. and i.p. route was more than 5000 and 3000 mg kg-1, respectively. All hematological parameters, with the exception of White Blood Cell (WBC) count, did not significantly differ in the experimental groups compared to the control group. No statistically significant differences were observed in serum cholesterol, triglyceride, blood urea nitrogen, Alkaline Phosphatase (ALP), Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) levels in the treatment groups when compared to the control group. These results suggest that the aqueous Jaft extract could be used safely in humans, particularly by the oral route.
  Ali Mirzaei and Nooshin Mirzaei
  For evaluation of 4 Iranian medicinal plant toxicity brine shrimp lethality assays Artemia salina and Artemia uramiana bioassay were used. A. urmiana and A. salina eggs were purchased and kept in a hatching chamber that containing artificial sea water for preparation of nauplii. The active nauplii were collected for study after 48 h. The Plantago major, Artemisia maritime, Mentha piperita and Borago officinalis were prepared in Yasuj, Iran and individually extracted with methanol, hexane and ethyl acetate by Soxhlet apparatus. The toxicity rate of extracts was estimated on the basis of the number of dead nauplii or mortality rate by Artemia salina and Artemia uramiana. LC50 values with 95% confidence intervals were determined by the probit analysis. All extracts, exception of B. officinalis displayed 100% mortality at 1000 μg mL-1 by A. urmiana and A. salina. Ethyl acetate extract was the most potent and presented the highest percentage of mortality with the lowest LC50 values by both assays too. After ethyl acetate, hexane extract showed the highest toxicity; however the methanol extract exhibited the lowest mortality. According to A. urmiana and A. salina toxicity results, trend of the extracts P. major>A. maritima>M. piperita>B. officinalis was reported. There was a positive correlation between the results from A. urmiana and A. salina, for detecting plants toxicity with a Pearson correlation of R2 = 0.989. A. uramiana assay is valuable for the screening of plant extracts to detect of toxicity.
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