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Articles by Ali Bandehagh
Total Records ( 2 ) for Ali Bandehagh
  Reza Shokri Gharelo , Ali Bandehagh , Neda Fattahi , Nasrin Nazarifar , Roghayeh Ghorbani and Morteza Derakhti Dizaji
  Background and Objective: Vacuole-type NHX proteins are important for plants’ ability to tolerate abiotic stress, especially salt stress. Materials and Methods: To gain information about the mechanisms of molecular regulation of NHX genes under abiotic stresses in canola (Brassica napus L.), in silico method was used to identify cis-acting regulatory elements present in 2.5 kbp upstream regions of identified vacuole-type NHX genes from the canola genome (BnNHXs). Results: A total of 51 cis-acting regulatory elements were identified that showed remarkable differences in frequency and site-specific distribution and they fell into five groups: Light-responsive elements, stress response, hormonal regulation, cellular development and elements with unknown function. The site-specific distribution of stress response and hormonal regulation elements indicated that they were most dense at -1600 to -1800 bp and at -800 bp, that is, far from the transcription start site. The most common motifs were the G-Box and Box 4 cis-elements, followed by the MBS, HSE and ARE motifs from the stress response group and the GARE-motif and ABRE from the hormonal regulation group. The results indicated that regulation of expression of BnNHXs under abiotic stresses involves TC-rich repeats, heat shock elements (HSE), LTR, anaerobic responsive element (ARE), Box-W1, MBS, CCAAT-box, ABA-responsive elements (ABRE), CGTCA-motif, TGACG-motif and ERE. Conclusion: This study provided information on the mechanisms by which BnNHX genes are regulated under abiotic stresses in canola.
  Fatemeh Zare Shahneh , Zohreh Babaloo , Behzad Baradaran , Fatemeh Hamzavi , Babak Bayazi and Ali Bandehagh
  Behçet’s Syndrome (BS) is a chronic recurrent multisystemic inflammatory disorder characterized by oral and genital ulcers, ocular inflammation. Behçet’s syndrome has a complex genetic etiology. However, epidemiological studies recommend that genetic factors have a significant influence to its pathogenesis, alike to other autoinflammatory disorders. Epidemiological statistics, clinical records and HLA typing were studied in Iranian Azari patients with Behçet’s syndrome. This investigation considered HLA associations with BS and HLA with certain clinical characteristics, age and sex in the (Tabriz) Iran which has an ethnically homogeneous population. HLA-A and HLA-B typing was performed in 290 BS patients, conforming to International Study Group criteria and in 300 blood donors, as controls. Patient records were retrospectively reviewed and patients reassessed clinically. HLA-B5, HLA-B35, HLA-51, HLA-B52 and HLA-CW4 presented significantly high frequencies in all patients. No other HLA type was associated. There was a significant HLA link with male sex in BS patients and Mean age (34±1.1) was determined. We present the frequency and correlation between Iranian Azari patients with Behçet’s syndrome and particular HLA antigens. Ninety nine percent had mouth ulceration, 64% genital ulceration, 72% skin lesions and 52% ocular involvement. This study supports HLA-B5, HLA-B35, HLA-51, HLA-B52 and HLA-CW4 immunogenetic predisposition in an ethnically homogeneous (Iranian Azari) population.
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