Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by Alexandre Kormanovski
Total Records ( 3 ) for Alexandre Kormanovski
  Maria C. Castillo-Hernandez , Eleazar Lara-Padilla , Alexandre Kormanovski , Jorge G. Perez-Tunon , Emilio M. Lopez-Calderon and Gustavo Guevara-Balcazar
  Tricyclic antidepressants are responsible for the majority of cases of intoxication due to psychoactive medications. Such intoxication results in an alteration of cardiovascular function. Sodium bicarbonate (HCO3) is the current treatment of choice, although, we propose Hyperbaric Oxygenation (HBO) therapy as an alternative treatment, since it is known to be an effective adjuvant therapy in the treatment of cardiovascular disease. However, the use and utility of this therapy has not been fully clarified. To evaluate hyperbaric oxygenation therapy as a collaborating agent in the treatment of amitriptyline intoxication, allowing recovery in a lesser period of time of the cardiovascular parameters under study, as compared to the sodium bicarbonate treatment. Male Wistar rats were intoxicated with amitriptyline and hyperbaric oxygen therapy or sodium bicarbonate were administered as a treatment. Blood pressure measures were taken and an electrocardiogram was performed to determine the heartbeat and the length of the QRS interval. After amitriptyline intoxication and first treatment with either HCO3 or HBO, heartbeat returned to normal and the length of the QRS segment was shortened. The latter parameter returned to normal after the second treatment with either SB or HBO. Whereas, HBO therapy normalized blood pressure after the first treatment, this result was found only after the second treatment with SB. The HBO therapy proved better than SB treatment for improving blood pressure.
  Gustavo Guevara- Balcazar , Eleazar Lara- Padilla , Alexandre Kormanovski , Israel Ramirez- Sanchez , Enrique F. Castillo- Henkel and Maria C. Castillo- Hernandez
  Oxidative stress and the antioxidant defense always seek balance in aerobic systems. Therefore, when O2 is added to an aerobic system during hyperbaric oxygenation, oxidative stress is induced and the antioxidant defense is stimulated. Dose-response curves were established for rat aorta exposed to different agonists. The aorta were from control rats and animals with 3, 10 or 20 HBO sessions. Parameters of vascular reactivity, oxidative stress and antioxidant defense were measured. With hyperbaric oxygenation, vascular reactivity was modified by the altered interaction between oxidative stress and antioxidant defense. The result was a low contractile response, possibly caused by endothelium dependent or independent pathways. Since, acetylcholine did not modify the vascular response, HBO seems to act by endothelium independent pathways related to nitric oxide. Hyperbaric oxygen therapy (HBO) led to an over 60% decrease in all parameters of oxidative stress and antioxidant defense (enzymatic and non-enzymatic) of thoracic aorta, an effect that lasted during the 20 sessions of HBO. This result indicates a probable drastic reduction in ROS and NO production, which could be explained by the capacity of an excess of oxygen to eliminate certain products that are normally involved in chain reactions leading to oxidative stress.
  Mayre Ivonne Bautista Albiter , Gustavo Guevara-Balcazar , Israel Ramirez-Sanchez , Alexandre Kormanovski , Maria E. Aguilar-Najera , Jesus Nolasco and Maria C. Castillo-Hernandez
  Background and Objective: Phosphide exposure is one of the most lethal types of poisoning because there is no specific antidote; therefore, the objectives of this study were to analyze the levels of oxidative and mitochondrial damage caused by poisoning and to determine whether gastric lavage with either olive oil or bicarbonate and hyperbaric oxidation therapy improves the recovery from this type of poisoning. Methodology: Female Wistar rats (300±30 g) were assigned to 1 of 5 groups. In groups with poisoned rats, 27 mg of aluminum phosphide was administered, after which some of the rats received treatment via gastric lavage (olive oil, 10 mg kg–1 or sodium bicarbonate, 1 mEq kg–1) and/or hyperbaric oxygenation therapy. The enzymatic activities of citrate synthase and catalase were measured in cardiac, liver and lung tissue and lactate levels were measured in plasma by spectrophotometry. Results: After phosphide administration, the results showed a reduction in the enzymatic activities of catalase, citrate synthase and lactate; however, after combining the gastric lavage of bicarbonate with hyperbaric oxygenation, the catalase and citrate synthase activities increased and the lactate activity returned to normal levels. Conclusion: It is concluded that combining hyperbaric oxygenation with gastric lavage exerted a protective effect by reducing the cellular damage and normalizing the enzymatic activities of catalase and lactate.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility