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Articles by Alaaeldin A. Hamza
Total Records ( 2 ) for Alaaeldin A. Hamza
  Alaaeldin A. Hamza
  Although treatment with therapeutic agents may be one of the main causes of liver toxicity, there have been only limited attempts at thorough research efforts to seek solution. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity. This DIC-induced hepatotoxicity was found to be associated with oxidative damage. In this report, extracts of herbal plants that are traditionally used for treating many illnesses were examined, namely Curcuma longa (CL), Glycyrrhiza glabra L (GL) and Moringa oleifera Lam (MO). They all showed a novel hepatoprotective effects against DIC–induced hepatotoxicity in rats. Administration of DIC at 150 mg/kg developed acute hepatic damage, as demonstrated by increased serum alanine aminotransferase (ALT) activity and histopathological changes. In addition, DIC treatment resulted in an increase in the hepatic malonialdehyde level and depletion in total antioxidant capacity, reduced glutathione content, catalase, and superoxide dismutase activities. Treatment with herbal extracts for 30 days before DIC treatment significantly ameliorated the indices of hepatotoxicity induced by DIC. In addition, these herbs alleviated DIC-induced oxidative changes in liver. These results suggest that CL, GL, and MO inhibit DIC-induced hepatotoxicity and might serve as a novel combination chemotherapeutic agent with DIC to limit its free radical-induced organ injury.
  Kaneez Fatima Shad , Suhail Al-Salam and Alaaeldin A. Hamza
  The therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg kg-1) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl contents and catalase activity (as markers of oxidative stress). The cardiotoxicity damage in DOX treated rats was accompanied by histo pathological changes such as necrosis and apoptosis in cardiac tissues. These biochemical and histological disturbances were effectively attenuated on pretreatment with sesame oil (5 mL kg-1). These data suggest that sesame oil may be a suitable cardio protector during DOX treatment.
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