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Three coordination complexes of metals with mixed ligands [Mn(ED)(2-ap)2,
A], [Fe(ED)(2-ab)2, B] and [Fe(ED)(2-ap)2, C] were tested
for their antimicrobial activity by disc diffusion and serial dilution methods.
All the complexes were active against various test pathogenic organisms. The
maximum antibacterial and antifungal activities were shown by the manganese
complex A. The minimum inhibitory concentration of the complex A was determined
against four pathogenic bacteria Bacillus subtilis, Streptococcus-β-haemolyticus,Escherichia coli and Salmonella typhi and values were found between 16-32 μg ml-1. The manganese complex A also showed potent cytotoxic effect which is indicative of its probable effect on cancer cell lines.
