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Articles by Akbar Idhayadhulla
Total Records ( 4 ) for Akbar Idhayadhulla
  Sujith Sugathan , Aseer Manilal , Joseph Selvin , Akbar Idhayadhulla , Radhakrishnan Surendra Kumar and M.V.N. Panikkar
  Seaweed-associated marine bacteria were recognized as a potential source of antimicrobial compounds. In the present study, a total of 27 epiphytic bacteria were isolated from four species of seaweeds collected from the Kollam coast (Indian Ocean) were investigated for antagonistic activity by cross streak method. Of the 27 bacterial isolates, 4 strains inhibited the growth of at least one shrimp vibrio pathogen tested. The active strains were further subjected to agar well diffusion assay. The result indicates that among the four seaweed isolates, SWI-24 strain exhibited highest spectrum of activity against all the tested shrimp pathogens. The molecular characterization based on partial 16S rRNA sequence revealed that the active isolate SWI-24 was Pseudoalteromonas sp. The efficient antagonistic potential exhibited by the SWI-24 against pathogenic shrimp bacteria may further reflect the potential use of seaweed-associated bacteria in managing the shrimp/fish disease.
  Akbar Idhayadhulla , Radhakrishnan Surendra Kumar , Abdul Jamal Abdul Nasser and Aseer Manilal
  The compounds of 2,2'-[(3,5-dimethyl-1H-pyrrole-2,4-diyl) dicarbonyl]dihydrazine carboxamide(2), 2,2’-[(3,5-dimethyl-1H-pyrrole-2,4-diyl)dicarbonyl]dihydrazine carbothioamide(3), 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazine carboxamide(5) and 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine -3,5-diyl]dicarbonyl}dihydrazine carbothioamide (6) were synthesized from hydrazinolysis method and synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds were screened for antimicrobial and anticancer activities. Evaluation of antibacterial, antifungal activity showed that the compounds exhibited better results than reference drugs. The newly synthesized compounds have been screened for preliminary anticancer activity against HepG2(Liver), Hela(Cervical), MCF-7(Breast) cancer cells. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
  Ashraf A. Mostafa , Abdullah N. Al-Rahmah , R. Surendra Kumar , Asser Manilal and Akbar Idhayadhulla
  In this study, to investigate the synthesis and characterization of some imidazolidine-2,4-dione,2-thioxoimidazolidin-4-one derivatives and synthesized compounds were evaluated for anticoagulant and anticancer activities. Compounds 2a-2h, 3a-3h, 4a-4h and 5a-5h were prepared by cyclization method. The synthesized compounds were confirmed by Fourier transform infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR), Mass Spectrometry (MS) and elemental analyses. The synthesized compounds were screened for MCF-7 breast cancer cell line and anti-coagulant activities. Anticoagulant activity was determined by Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) coagulation assays. Compound 3-(2,6-bis (4-methoxyphenyl)-1,3-dimethylpiperidin-4-ylideneamino)-2-thioxoimi dazolidin-4-one 5f (>1000 in APTT assays) was highly response in anticoagulant screening compared with the reference of heparin while the compound 3-{[-1,3-Dimethyl-2,6-di (4’-nitrophenyl) piperidin-4-ylidene]amino}imidazolidine-2,4-dione 3e (LD50: 20.4 μg mL–1 was highly active against MCF-7 breast cancer cell line compared with the reference. Therefore, the compounds 5f and 3e are novel and beneficial for the development of anticoagulant and anticancer agents.
  Aseer Manilal , Nooruddin Thajuddin , Joseph Selvin , Akbar Idhayadhulla , Radhakrishnan Surendra Kumar and Sugathan Sujith
  A total of twenty marine algae were collected from the rocky intertidal and subtidal regions of the southwest coast of India and extracted in methanol. The extracts were evaluated for larvicidal activity against the second and third instar larvae of the human vector mosquito Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Analysis on the activity profile of the above marine algae indicated that the early stage larvae were very sensitive to seven seaweed extracts that had been tested. Among the seven marine algae, Lobophora variegata was highly potential, showing LD50 value of 70.38 and 79.43 μg mL-1 on the 2nd instar larvae of A. aegypti and C. quinquefasciatus respectively. The rank of larvicidal potency in highly active algae in the descending order is as follows: Lobophora variegata (Dictyotaceae)>Spatoglossum asperum (Dictyotaceae)>Stoechospermum marginatum (Dictyotaceae)>Sargassum wightii (Sargassaceae) >Acrosiphonia orientalis (Acrosiphoniaceae)>Centroceras clavulatum (Ceramiacea)>Padina tetrastromatica (Dictyotaceae). This is the first report that envisaged the mosquito larvicidal efficacy of L. variegata from the Indian coast. Therefore, this marine alga could be recognized as a potential resource of natural insecticide and can be developed to replace synthetic insecticides in future.
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