Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Ahmida Mohamed
Total Records ( 1 ) for Ahmida Mohamed
  Elsayed Emara and Ahmida Mohamed
  The study was designed to investigate the effects of combined antioxidants of vitamins C [L-ascorbic acid] and E [DL-α-tocopherol] on endothelial inflammation biomarkers and oxidative stress in liver and kidney in streptozotocin (an i.p. single 40 mg kg-1 dose) induced diabetic rats. Concentrations of interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1(VCAM-1), lipid peroxidation product, thiobarbituric acid reacting substance (TBARS) and activities of glutathione peroxidase (GHP-Px), catalase (CAT) and superoxide dismutase (SOD) enzymes were compared in 3 groups of 10 rats each: control nondiabetic rats [group I], untreated diabetic rats [group II] and diabetic rats treated with vitamins C (200 mg kg-1day-1 i.p.) and E (100 mg kg-1day-1 i.p.) for four weeks [group III]). The rats in groups II had significantly (p<0.05) higher levels of blood glucose, Total Cholesterol (TC), triglycerides (TG), IL-6, TNF-α, ICAM, VCAM and TBARS than rats in group I. In addition, the rats in group II had significantly (p<0.05) lower activities of GHP-Px, CAT and SOD than group I. The treatment with vitamins C and E significantly (p<0.05) lowered blood glucose, TC, TG, IL-6, TNF-α, ICAM and VCAM levels by 36, 48, 34, 23, 23, 22 and 14%, respectively. Also, lowered TBARS levels and increased the antioxidant enzyme levels near to control values. The results verify the presence of oxidative stress in diabetes and suggest beneficial effects of combination vitamins C and E in combating the oxidative stress in this disease.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility