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Articles by Ahmet AYDIN
Total Records ( 2 ) for Ahmet AYDIN
  Ahmet Aydin , Gonca Alak , Esat Mahmut Kocaman and Muhammed Atamanalp
  Carboxin is one of the most widely used fungicides in agriculture but information about toxicity on fish is limited. The aim of this study was to determine the effects of exposure to carboxin on the Antioxidant Defense System of rainbow trout (Oncorhynchus mykiss). The fish were exposed to carboxin (3.85 ppm) for 7 days. The antioxidant parameter (Glutathione-S-Transferase (GST)) was measured in fish liver samples. The results indicated that carboxin exposure significantly affected the activity of GST in rainbow trout liver (p<0.01). Thus, it was assumed that carboxin caused oxidative stress in rainbow trout and GST enzyme played a role in protection against carboxin toxicity.
  Cemal AKAY , Ismail Tuncer DEGIM , Ahmet SAYAL , Ahmet AYDIN , Yalcuin OZKAN and Husamettin GUL
 

Aims: Determinations of drug impurity and drug degradation products are very important from both pharmacological and toxicological perspectives. Establishment of monitoring methods for impurities and degradation products during pharmaceutical development is necessary because of their potential toxicity. The aim of this study was to develop a rapid and simultaneous determination method for paracetamol and acetylsalicylic acid (ACA) and their degradation and toxic impurity products by high performance liquid chromatography (HPLC) in pharmaceutical dosage forms.

Materials and Methods: A reverse phase (RP)-HPLC method for the simultaneous analysis of paracetamol, ACA, and ascorbic acid and their degradation and impurity products such as salicylic acid (SA) and p-chloroacetanilide was developed and applied to the determination of these compounds in commercial dosage forms. These compounds were well separated on a Bondapak C18 reverse phase column using a mobile phase consisting of a mixture of methanol: water (35:65; v/v) adjusted to pH 3.1 with 10% orthophosphoric acid at a flow rate of 1.8 ml.min-1 and the effluent was monitored at 235 nm. Sulfamethoxazole was used as an internal standard.

Results: The proposed method was linear in the ranges of 0.5-4.0, 0.75-6.0, 0.75-6.0, 1.0-12.0 and 1.0-12.0 µg m1-1 for paracetamol, ACA, ascorbic acid, SA and p-chloroacetanilide, respectively. Relative standard deviations for repeatability, reproducibility and recovery were below 2%.

Conclusions: In this study, a RP-HPLC method, which is simple, rapid and does not require any separation step for each drug, was successfully applied for the quantitative assay of paracetamol, ACA, ascorbic acid, and their degradation and toxic impurity products in commercial tablet dosage forms.

 
 
 
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