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Articles by Ahmed M. Naglah
Total Records ( 3 ) for Ahmed M. Naglah
  El-Sayed M. Lashine , Abdel Fattah Haikal , Mansour E. Abou Kul , Lina A. Nasrallah and Ahmed M. Naglah
  The present study describes the synthesis of some novel analogues (I-IV) of an anti-inflammatory peptide-based drug called Oxpholipin-11 D. Chemical modifications in the peptide chain sequences were introduced to the parent compound, aiming to enhance the potency and penetration properties of the resulting peptide analogues. These novel compounds were characterized by means of their amino acid analysis, FT-IR and HPLC-ESI-mass spectra. The biological evaluation of the obtained compounds showed increased anti-inflammatory activity of the analogues I, II and IV compared to the reference drug.
  Ahmed M. Naglah , Mohamed A. Al- Omar , Samy M. El- Megharbel and Moamen S. Refat
  Metal complexes have been applied as medicinal agents in the treatment of different human infections and diseases. So, the aim of this study is focused on studying the spectroscopic, thermal and evaluating antimicrobial investigations of ibuprofen analgesic drug complexes formulas with Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) metal ions. Complexes of Cu (II), Ni (II), Ag (I), Hg (II), UO2 (II), Cd (II), Ba (II) and Al (III) with ibuprofen ligand as to evaluate the biological activity were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV-VIS, IR, 1H-NMR spectroscopy and thermal analysis. The IR spectral data suggested that the ibuprofen ligand behaves as a monobasic bidentate ligand towards the central metal ion with deprotonated of carboxylic group. From the microanalytical data, the stoichiometry of the complexes 1:1, 1:2 and 1:3 (metal: ligand) was found. The metal complexes were screened for antibacterial activity against Gram -ve organisms as Escherichia coli and Pseudomonas aeruginosa, Gram +ve organisms as Bacillus subtilis and Bacillus cereus and antifungal organisms such as Aspergillus niger, Aspergillus flavus and Aspergillus oryzae. The resulted Ibu compounds has proved the thermal stability feature. The antimicrobial activities of the metal complexes of Ibu recorded a significant effect against some bacteria and fungi.
  Ahmed M. Naglah , Mohamed A. Al- Omar , Abdel Majid A. Adam and Moamen S. Refat
  Saccharin (sacH) is a sugar substitute sweetening agent used extensively in dietary products. It is about 300 times sweeter than sucrose. This study highlighted the structural chemistry of Charge Transfer (CT) complexes formed from the interactions of two acido acceptors (CLA and PA) with sacH. The IR and 1H NMR revealed evidence of significant intermolecular interactions between N-H group in the sacH and O-H group in the acido acceptors based on their characteristic shifts. The TG and DTA experiments were carried out to investigate the thermal properties of the obtained complexes. Their morphological features were also investigated using Optical Light Microscope (OLM). The OLM micrograph patterns indicate the formation of high quality colored crystals. This study provided the essential basics for understanding the complexation chemistry of saccharin.
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