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Articles by Ahmed M. Aboul-Enein
Total Records ( 2 ) for Ahmed M. Aboul-Enein
  Ahmed M. Aboul-Enein , Farouk K. El Baz , Gamal S. El-Baroty , A.M. Youssef and Hanaa H. Abd El-Baky
  The antioxidant of seven algal extracts was evaluated by decrease the thiobarbituric acid reactive substance (TBARS) produced from lipid peroxidation of liver microsomes induced by Fe++/ascorbate, Fe++/H2 O2 and CCl4 model systems. All algal extracts had significant effect to prevent the production of TBARS in all oxidizing model systems and this phenomenon was increased by increasing their concentration. The values of inhibition % of TBARS generate from Fe++/ascorbate, Fe++/H2 O2 and CCl4 model system by Dunaliella salina were 100, 94.43 and 90.9% respectively, (at 15 min) at concentration level 200 ppm, while the inhibition values were 98.49, 89.8 and 88.8% at 100 ppm. This extract possesses higher antioxidant activity with average 2 times than the BHT at the same concentration level (100 ppm). On the other hand, mutant strains extract of Scenedesmus dimorphus, Scenedesmus acutus and Chlorella ellipsoida showed higher antioxidant activity than the normal cells extracts. The most of all algal extracts showed more potent as an antioxidant than the BHT which, is one of the powerful synthetic antioxidant agent. The antioxidant activity of algal extract and BHT against the induced lipid peroxidation in all model system were in the following descending order: Dunaliella salina > Sc. dimorphus mutant = Chlorella mutant > Sc. dimorphus normal > Chlorella normal > Sc. acutus (mutant) > Sc. acutus (normal) > BHT. The antioxidant activity of algal extracts on induced lipid peroxidation in different model system was dependent on the chemical composition of their extracts which containing mainly the carotenoids, tocopherol and vitamin C. These substances can protect lipid peroxidation in all model system by different mode of action. Therefore, micro algae extracts inhibited the lipid peroxidation products by scavenging reactive oxygen species (OH, O¯ and 1O2) and chain reaction breaking consequently its protect bodies from harmful effect of their substances.
  Farouk K. El-Baz , Ahmed M. Aboul-Enein , Gamal S. El-Baroty and Hanaa H. Abd El-Baky
  A total 14 vitamin algal extracts obtained from 7 strains (Dunaliella salina, Scenedasmus dimorphus (mutant), Chlorella (mutant), Scenedasmus dimorphus (normal), Chlorella (normal), Scenedasmus acutus (mutant) and Scenedasmus acutus (normal) grown under different environmental conditions, were tested for their ability to induce increased activity of the detoxifying enzyme system glutathione-S-transferase (GST) in several target tissues of female mice. In the normal algal extracts, increase of GST activity was ranged from 3 to 4.27, 1.99 to 2.77, 2.1 to 2.99 and 1.6 to 2.4 while the extracts obtained from the mutant algae, increase of GST activity was ranged from 4.29 to 6.79, 3.34 to 5.81, 3.64 to 4.37 and 2.31 to 3.19 times in the liver, small intestine, large intestine and lung, respectively as compared to control group. The vitamin extracts of D. salina were increased GST activity with 7.2, 6.21, 5.63 and 2.91 times than the control group in liver, small intestine, large intestine and lung tissues, respectively. Consequently, the vitamin extracts were evaluated to induce GST activity in different organs tissues of tumorous mice. The vitamin extracts of Dunaliella grown under stress conditions showed the most active extract that induced GST enzyme activity over all control groups including non-tumorous, tumorous (negative) and positive control groups (standard vitamins mixture). In liver, the GST activity was increased over the control groups by 8.12, 6.0 and 3.0, respectively. The data indicating that vitamin algal extracts were increase GST activity in tumorous tissues over than tumorous control group in all tissues examined suggested a correlation between the GST-induced ability in tumorous and inhibitory of tumorigeneses. Since, the ability to induce an increase in the detoxifying enzyme activity by natural compounds has been found to correlate with their activity in the inhibition of tumorigeneses. Therefore, algae extracts may be considered as a potential chemopreventive agent.
 
 
 
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