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Articles by Ahmad Almatroudi
Total Records ( 2 ) for Ahmad Almatroudi
  Mohammed A. Alsahli , Ahmad Almatroudi , Amjad Ali Khan , Fahad Abdulrahman Alhumaydhi , Faris Alrumaihi and Arshad Husain Rahmani
  Background and Objective: Figs are recognised to contain a number of pharmacological properties without any adverse effect. The present study aimed to evaluate the protective role of fig fruit extract on CCl4-induced hepato-toxicity. Materials and Methods: The mice were randomly divided into 4 groups, Group I mice, vehicle treated were kept on normal diet and served as normal control. Group II mice, received fig extract only, Groups III, received CCl4 only and served as disease control group. Group IV mice, labelled as treatment group, received CCl4+fig fruit extract (100 mg kg–1 b.wt.). Results: CCl4-induction causes significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) level and decrease in antioxidant enzymes levels. Administration of fig extract significantly restore the CCl4-induced alterations in the liver enzymes and antioxidant enzymes and such differences were statically significant (p<0.05). Histopathology of the liver tissue revealed that administration of fig fruits extract reduced inflammatory cell infiltration and blood vessel dilation and showed role in the maintenance of hepatocytes architecture whereas, severe tissue alterations was noted in CCl4 treated group. Conclusion: The overall findings, indicate that fig fruit extract is useful in preventing liver injury against CCl4-induced hepato-toxicity through its antioxidant enzyme activities and shows role in the maintenance of hepatocyte architecture.
  Saleh A. Almatroodi , Ahmad Almatroudi , Fahad Saleh Almasnad , Amjad Ali Khan , Ali Yousif Babiker , Abdulmohsen M. Alruwetei and Arshad Husain Rahmani
  Background and Objective: Curcumin, an active compound derived from turmeric (Curcuma longa) was noticed to have health promoting effects through modulating various biological activities. The present study was carried out to assess the hepatoprotective effect of curcumin in CCl4-induced hepatotoxicity rats. Materials and Methods: Liver function enzymes activity was evaluated using the spectrophotometric method. The levels of inflammatory markers were measured using the enzyme-linked immunosorbent assay (ELISA) method. Moreover, antioxidant enzymes (Catalase, glutathione-S-transferase) were assayed in the serum calorimetrically. Haematoxylin-eosin staining was performed to examine the histopathological changes. In addition, expression of vascular endothelial growth factor (VEGF) protein was evaluated through immunohistochemical staining. Statistical comparison between groups was made via using SPSS software by matching analysis of variance. A p<0.05 was measured to be statistically significant. Results: Oral administration of CCl4 into rats for 8 weeks had resulted in significant decrease of the serum level of the antioxidant enzymes including superoxide dismutase (SOD) and catalase. It had also significantly increased the serum level of the liver function enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and proinflammatory markers. Oral administration of 50 mg kg1 b.wt., of curcumin evidences a significant protection against CCl4 induced liver damage as measured in terms of liver function enzymes, antioxidant enzymes, inflammatory markers and histopathological parameters. Moreover, curcumin treatments protected against CCl4-induced liver damage by maintaining histological damage. Conclusion: Based on these findings, it is concluded that antioxidant effect of curcumin could protect liver injury and normalize the architecture of hepatocytes against CCl4 induced toxicity
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