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Articles by Agik Suprayogi
Total Records ( 2 ) for Agik Suprayogi
  Min Rahminiwati , La Ode Sumarlin , Agik Suprayogi and Aryani Satyaningtijas
  Diabetes Mellitus (DM) is a group of metabolic disorder characterized by hyperglycemia due to damage in insulin secretion, insulin action or both. One of the diabetes mellitus group is diabetes mellitus type 2. Diabetes accounts type 2 for most of the data of DM patients which reached 90-95% of the total diabetics population. One of the plants as a potential alternative antidiabetic drugs is (Cynometra cauliflora) Namnam plant. This research will test the ability of glucose absorption by muscles of the isolated diaphragm of Sprague Dawley rat by Namnam (Cynometra cauliflora) leaf methanol extract at various concentrations. The result shows that an increase in glucose uptake by diaphragm when concentration of Namnam (Cynometra cauliflora) leaf extract and the highest increases in the concentration of 450 mg dL–1 with the uptake of 42.54±3.23 mg dL–1/30 min. Increased uptake of glucose also occurs when insulin 0.25 IU mL–1 is combined with methanol extract of namnam leaf (EMDN) at concentration of 450 mg dL–1 of 92.19±9.74 mg dL–1/30 min. Therefore, the namnam leaf (Cynometra cauliflora) plant has potential as antidiabetes type 2 drug through mechanism of the increased glucose uptake into cells.
  I. Made Tangkas , Ahmad Sulaeman , Faisal Anwar , Agik Suprayogi , Sri Estuningsih and Umi Faza Rokhmah
  Background and Objective: The results of previous studies have indicated that undernutrition that occurs during pregnancy can result in the slowing of fetal growth. Intrauterine growth retardation (IUGR) caused by malnutrition will have a negative effect on organogenesis, including kidney growth (nephrogenesis). This study aimed to evaluate the potency of bone marrow obtained from a local beef livestock practice in Central Sulawesi of Indonesia to increase the success of pregnancy and to prevent the slowing of fetal kidney growth during pregnancy. Materials and Methods: This experimental laboratory study with animal models used a complete randomized design (CRD) with a single factor. The bone marrow was obtained from the Tawanjuka Palu slaughterhouse of Central Sulawesi in Indonesia. A standard feed, an intrauterine growth retardation feed and a substitution isocaloric feed with bone marrow were formulated. The intervention was applied to rats during pregnancy with the feed available ad libitum. After birth, the offspring underwent lactation until the age of 22 days and then weaned and given standard feed. At the age of 30 days, the kidneys were removed and weighed. The kidney weight data were analyzed using a descriptive statistical test and a Wilcoxon test using SPSS version 23. Results: The results of the descriptive analysis indicate that there was a positive trend in response to the feed with the bone marrow but Wilcoxon analysis showed no significant difference in kidney weight between the control and intervention groups. Conclusion: Feed formulations containing bone marrow from local cattle have the potential to prevent slowing of kidney growth during pregnancy and increase the success of pregnancy.
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