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Articles by Afaf Ezzat
Total Records ( 3 ) for Afaf Ezzat
  Khaled Al -Menabbawy , Asaad El-Gerzawy , Afaf Ezzat and Hesham Mottawie
  Twenty two cases diagnosed as Attention Deficit Hyperactivity Disorder (ADHD), aged 6-10 years, chosen to study the correlation between developmental, behavioral and genetic factors in relation to some biochemical parameters. Another group of 22 healthy normal children of the same matched age and sexes were collected as control group. All cases and control children were subjected to full clinical and neurological history and examination, anthropometric measurements and behavioral assessment. Levels of folic acid, vitamin B12 and T3, T4 were estimated, for both cases and controls. Cytogenetic examination of peripheral blood lymphocytes were done for cases only. Chromosomal abnormalities were detected in 6 cases out of 22 cases. There was a significant decrease in the weight and BMI, as compared with controls, these decrease was highly significant among those with chromosomal abnormalities. Regarding the behavioral assessment, a significant decrease in three of the four components of Vineland Adaptive behavior scale: (communication, daily living skills and socialization), as compared with controls, this decrease in the three components was highly significant among those with chromosomal abnormalities. A non significant increase in the score of the motor skills, as compared with controls, while significant increase in it`s score was found among those with chromosomal abnormalities. Biochemical studies showed no significant decrease in T3 and T4 levels as compared with controls, while levels of Folic acid and Vitamin B12 showed significant decrease as compared with controls, this decrease in their levels showed highly significant decrease among those with chromosomal abnormalities. We concluded that this study is the first study in our knowledge examining the correlation between developmental, behavioral and genetic factors among children with ADHD in the same subject group. ADHD is multifactorial and is associated with a remarkable increase in chromosomal abnormalities, which affect behavior and anthropometric measurements.
  Hala T. El-Bassyouni , Adel M. Ashour , Afaf Ezzat , Randa Bassiouni and Ekram M. Fateen
  Galactosemia is an autosomal recessively inherited disorder of galactose metabolism. It has good prognosis, if detected in neonatal period or early infancy. Treatment consists of life long dietary restriction of galactose. Present study included eight patients with galactosemia on dietary treatment, five of them had galactose-1-phosphate uridyltransferase deficiency known as classical galactosemia and three had uridine-diphosphate galactose-4` epimerase deficiency. Clinical evaluation of patients under galactose restricted diet and assessment of the antioxidant status in response to dietary therapy was done. Delayed milestones were present in all patients, jaundice at birth was present in 4 and low birth weight was present in 3 patients. Craniofacial dysmorphism was present in 5 patients. Hepatomegaly was present in 6 patients. MRI of the brain showed brain atrophy in 3 patients and demyelination in 2 patients. There was cataract in 7 patients. The levels of zinc, copper, iron, calcium, phosphate, magnesium, selenium, manganese, ß-carotene and vitamin A were evaluated in the blood of galactosemic patients on galactose restricted diet and a comparison between trace elements, ß-carotene and vitamin A in studied patients with galactosemia and controls was done. Copper, calcium, phosphate, manganese and ß-carotene levels in blood were significantly decreased in our patients (p<0.001) than in controls. These findings suggest that patients on galactose restricted diet are at risk of oxidative stress. The data emphasize the importance of dietary supplementation with an antioxidant containing ß-carotene, calcium, copper, selenium and manganese to inhibit oxidative stress in these patients. Consequently this will minimize the neurological deficits improve bone mineralization, reduce the development of retinopathy and damage to liver cells in patients with galactosemia.
  Thanaa E. Hamed , Afaf Ezzat and Sahar Y. Al-Okbi
  The present research dealt with the evaluation of the anti-diarrheal activity of two therapeutic diets in model of castor oil induced diarrhea in rats. Formula I contain modest amount of skimmed milk, formula II was lactose restricted diet. Both formulae contain cereals, legumes, honey and edible source having anti-diarrheal activity. The nutritional value of the two formulated therapeutic diets was evaluated in normal growing rats in comparison to reference formula, milupa special formula, in addition to control balanced diet (contain 10% protein supplemented from casein). The evaluation of nutritional value depended on determination of total food intake, body weight gain, food efficiency ratio and protein efficiency ratio. Nutritional status of rats fed different diets was also evaluated through determination of certain biochemical parameters such as percentage haematocrit, blood haemoglobin concentration, plasma total protein, albumin, iron, phosphorus, zinc, magnesium, retinol and β-carotene. Results showed that anti-diarrheal activity of formula I was superior compared to formula II. Milupa and formula I have higher values of protein efficiency ratio and food efficiency ratio than control casein diet which were significant in case of Milupa. However diet II showed comparable values to control. Biochemical parameters showed higher values of plasma total protein, magnesium and retinol of rats fed Milupa diet. Feeding diet II produced significant increase of plasma iron magnesium and retinol. However, only significant increase of plasma magnesium has been observed when feeding diet I.
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