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Articles by Adriyan Pramono
Total Records ( 2 ) for Adriyan Pramono
  M. Zen Rahfiludin , Adriyan Pramono and Onny Setiani
  The immune response plays an important role in leprosy prevention. Here we analyzed the effect of vitamin A, zinc and vitamin E supplementation on the immune response in seropositive leprosy patients by measuring serum levels of retinol, zinc, α-tocopherol, interferon gamma (IFN-γ) and interleukin-2 (IL-2). Subjects were randomly divided into either the treatment or control group. The treatment group received high dose vitamin A once and a daily dose of Zn and vitamin E supplementation for 45 days, while the control group received pills that were identical in appearance but lacked supplements. Supplement consumption compliance was recorded weekly. After 45 days of supplementation, IFN-γ and IL-2 levels were measured again. Upon study initiation both groups had normal retinol, zinc and α-tocopherol serum levels. After 45 days, serum levels of retinol and α-tocopherol increased only in the supplementation group (p = 0.046 and p = 0.033, respectively), while zinc serum levels decreased in both the supplementation (p = 0.001) and placebo (p = 0.000) groups. IFN-γ levels decreased slightly in the supplementation group, although the change was not significant (p = 0.098). Meanwhile, IFN-γ levels in the control group decreased significantly (p = 0.022). IL-2 levels decreased slightly in both the supplementation and placebo groups, but the changes were not significant (p = 0.421 and p = 0.556, respectively). Together our results indicate that supplementation with zinc and vitamins A and E could be a useful alternative therapy for maintaining immune response of seropositive leprosy patients.
  Adriyan Pramono , Nuryanto , Etisa Adi Murbawani , Binar Panunggal and Gemala Anjani
  Metabolic syndrome (MetS) plays an important role in inflammation and insulin resistance. Increasing number of adolescents MetS were common among obese. The inflammatory biomarkers may contribute to increasing levels of uric acid (UA). Currently UA is not only associated with gout, but also cardiovascular disease. This was a cross sectional study conducted in Semarang City, Indonesia. Consecutive sampling for obese adolescents was administrated. About 81 obese adolescents from two government highs schools were recruited in this study. We measured anthropometry (weight, height, waist circumference, neck circumference), clinical data (systolic and diastolic blood pressure) and biochemical data (triglyceride, HDL-cholesterol, fasting blood glucose, uric acid). A subjects was categorized as MetS if presence 3 or more components of MetS. Gender and Hyperuricemia was associated with presence of MetS (p = 0.048 and p = 0.004). The mean levels of UA increased accordance to the amount of MetS components (p = 0.000). Regression logistic analysis concluded that hyperuricemia as major risk factor of MetS among obese adolescents (OR = 3.97). Hyperuricemia contributed to metabolic syndrome among Indonesian obese adolescents.
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