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Articles by Adel S. Al-Zubairi
Total Records ( 6 ) for Adel S. Al-Zubairi
  Ahmad Bustamam , Siddig Ibrahim and Adel S. Al-Zubairi
  Herbal dugs could be a new source for inhibitors of acetyl cholinesterase (anti-AChE), the key enzyme in the breakdown of acetylcholine and a new talented approach for the cure of elderly neurologically associated disorders such as Alzheimer’s disease (AD). Zerumbone (ZER) is sesquiterpene from the edible plant, Zingiber zerumbet which is known to possess tremendous biological activities. In this study, the inhibitory effect of ZER towards acetyl cholinesterase was evaluated using thin layer chromatography (TLC) bioautography and compared concurrently to tacrine, as positive control. The results obtained in this research showed that ZER has an enzymolytic effect towards AChE. It could be suggested that ZER might be a potential candidate for the development of anti-AD treatment.
  Ahmad Bustamam , Siddig Ibrahim , Nirmala Devi , Muhd Nazrul Halkim , Adel S. Al-Zubairi and M.M. Syam
  Cervical cancer is the second most common cancer of female reproductive tracts. In developing countries, cervical carcinoma is the leading cause of cancer fatality in women. Despite attempts to lower the fatality rate, very few in vivo models are in place to investigate this cancer. We therefore are able to develop an in vivo animal model that is suitable to conduct such study. In our attempt to secure an in vivo animal model for cervical cancer, the carcinogenic property of diethylstilboestrol (DES) was exploited to establish a model for Cervical Intraepithelial Neoplasia or carcinoma (CIN). Female Balb/C mice were injected with several dosages of DES (i.p) during pregnancy at day 13-18. Female offspring were reared and sacrificed at age of 48-54 days and the cervix tissues taken for histological evaluation using H and E. The progression of the cancer and hence, disease state is monitored by measuring serum IL-6 using an ELISA kit. Proliferative cell nuclear antigen (PCNA) expressions were studied by implying immunohistochemical techniques. All parameters with regards to CIN were compared to a control group of treating the cancer using a used drug, cisplatin, used preferentially to treat cervical cancer in humans. The results of this study revealed that a significant difference in serum IL-6 concentration between DES-treated group and control groups (p<0.05). CIN histological related lesions was noticed to be prominently dominant in DES-treated animals whilst these lesions were absent in control groups. In addition to that PCNA index in DES-treated animal was found to be a significant different compared to control group. The above findings indicate that DES could be utilized and further exploited as cervical carcinogenesis initiator in animal models to screen and study new potential anti-cervical cancer compounds in vivo.
  Adel S. Al-Zubairi
  Zerumbone (ZER) is a natural compound isolated from Zingiber zerumbet smith, family Zingiberaceae. It has been demonstrated to have an in vitro antiproliferative effects against various human tumour cells as well as in vivo against a number of induced malignancies in mice. The aim of our study was to assess the genotoxicity of ZER in CHO cells and using the bacterial mutagenicity ‘Ames assay’. The Methyl Thiazol Tetrazolium (MTT) screening assay was carried out to determine the cytotoxicity index (IC50) of ZER. The average IC50 value was 20.8 (±5.1) μM. Two cytogenetic end points were used to investigate the clastogenic effects of ZER, namely Chromosomal Aberrations (CA) assay and Micronucleus (MN) test. The micronucleus test and chromosome aberrations induction assay were performed without any metabolic activation. In the bacterial reverse mutagenicity assay (Ames test), there was no mutational change observed in Salmonella Typhimurium strain TA100 in the presence or absence of S-9 liver metabolic activation system. In contrast, MN induction and the frequency of chromosome aberrations in cultures treated with ZER increased significantly and dose-dependently. Chromatid and whole chromosome breaks/gaps, as well as dicentrics, interchanges, endoreduplications and ring chromosomes were the main types of aberrations induced by ZER. However, higher concentration was found to be toxic.
  Haider Al-Mamary , Amina El-Shaibany , Molham Al-Habori , Ali Al-Meeri , Adel S. Al-Zubairi and Mohamed Al-Mamary
  Animals fed Catha edulis leaves develop an acute hepatitis and long-term feeding is associated with chronic active hepatitis and fibrotic liver disease. Repeated episodes of subclinical hepatitis with evolution to chronic liver disease has also been observed in patients chewing Catha edulis leaves. The aim of this study was to examine the effect of 10% Catha edulis on enzyme markers of carcinogenicity in relation to chemically-induced hepatocellular carcinoma in rabbits. Forty healthy male white New Zealand rabbits were allocated to one of five groups (eight rabbits per group). Two control groups fed on control diet with or without sodium nitrite+diethylamine, two treatment groups fed on a diet containing 10% Catha edulis with or without sodium nitrite in water and a fiveth group fed on diet containing tannin. Fasting blood samples were collected at different time intervals (1, 8 and 20 weeks) and plasma was assayed for γ-glutamyl transpeptidase, β-glucuronidase, LDH, AST and ALT using enzymatic kits. 10% Catha edulis alone did not affect these enzymes, however, animals maintained on 10% Catha edulis and sodium nitrite (4000 ppm) (58.82 mM) significantly increased the activities of γ-glutamyl transpeptidase, β-glucuronidase and LDH in a similar manner to those animals exposed to both carcinogens (nitrosamine precursors and commercial tannin). This raises the question of whether the Catha edulis hepatoxicity could be attributed to possible formation of nitrosamines in vivo from the secondary amines present in Catha edulis leaves; as well as highlighting the significance of these enzyme markers in early detection of chemically-induced HCC.
  Ahmad B. Abdul , Siddig I. Abdelwahab , Adel S. Al-Zubairi , Manal M. Elhassan and Syam M. Murali
  The aim of this study is to evaluate the anticancer and antimicrobial activities of zerumbone (ZER) from the rhizomes of Zingiber zerumbut. ZER is a crystalline sesquiterpene from the wild ginger, Z. zerumbet. This bioactive component has its unique structure, with a cross-conjugated ketone in an 11-membered ring, as well as remarkable biological activity. Thus, this compound has been isolated from the fresh rhizomes of Z. zerumbet using steam distillation and evaluated for its antimicrobial and anticancer activities. The antimicrobial effects were examined using disc diffusion method and group of microorganism, namely known as Methicilin resistant Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella choleraesuis, Bacillus subtilis, Candida albicans, Aspergillus ochraceaus and Sacchoromyces cerevisiae. However, MTT assay was performed to determine the anti-cancer properties of zerumbone on human cervical cancer cells (HeLa) compared to cisplatin as positive control. Zerumbone has shown a dose dependent (p<0.05) anti-bacterial effect on S. choleraesuis, while no antifungal activity were observed. Zerumbone was also able to exert an antiproliferative effect towards cervical cancer cell line (HeLa) in time-dependent manner (p<0.05) (24, 48 and 72 h). It could be concluded that, zerumbone with its unique chemical structure and versatile pharmacological activities might be a potential primer to develop new curative agents for possible various ailments.
  Zakaria Al-Shoaibi , Mohamed A. Al-Mamary , Molham A. AL-Habori , Adel S. Al-Zubairi and Siddig I. Abdelwahab
  Palm date fruits have been used extensively for the traditional cure of liver illnesses and malaria in the Arab Peninsula. Therefore, the aim of the present study was to evaluate for the first time the in vivo hepatoprotective and the antioxidative effects of different varieties of palm date fruits in relation to their total phenolic contents and total flavonoids. This study was carried out using the CCl4-induced liver injuries in rabbits for two different periods: 4 and 20 h after CCl4-subcutaneous injection and oral administration of palm date syrups (5 g kg-1 b.wt.). The antioxidative and hepatoprotective effects of palm date syrups during the first and second experimental periods (4 and 20 h) were very clear, since results of plasma ALT and AST and TBARS (from liver homogenate) of the control were significantly higher than those obtained from animals treated with syrups. The present findings do strongly recommend to increase the consumption of palm date fruits, especially in cases of liver diseases and for the prevention of other serious diseases such as cardiovascular and cancers.
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