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Articles by Achida Jaruchotikamol
Total Records ( 3 ) for Achida Jaruchotikamol
  Pawitra Pulbutr , Natcha Saweeram , Thitiworada Ittisan , Hattaya Intrama , Achida Jaruchotikamol and Benjamart Cushnie
  Background: Coccinia grandis (ivy gourd) an edible plant widely consumed in many Southeast Asian countries has been used traditionally for the treatment of diabetes mellitus. However, its role in the regulation of carbohydrate-digesting enzymes, especially α-amylase and α-glucosidase has not been clearly established. Materials and Methods: The aqueous leaf and stem extracts of Coccinia grandis (the CGL and the CGS extracts, respectively) were prepared and their actions toward in vitro activities of α-amylase and α-glucosidase were examined. The activities of α-amylase and α-glucosidase were indicated by the amounts of maltose and p-nitrophenol generated in the reactions, respectively. Results: The CGL and the CGS extracts possessed an α-amylase inhibitory action with the IC50s of 8.09±0.72 and 8.06±1.27 mg mL–1, respectively. The CGL extract produced a mixed inhibition against α-amylase, whilst the CGS extract inhibited the enzyme in an uncompetitive manner. The CGL and the CGS extracts exhibited an inhibitory action against α-glucosidase enzyme with the IC50s of 77.66±9.16 μg mL–1 and 0.75±0.11 mg mL–1, respectively. Both extracts acted as mixed enzyme inhibitors against α-glucosidase. Conclusion: These results support the traditional use of Coccinia grandis in diabetic patients, especially for the control of postprandial plasma glucose level. However, further studies on identification of the active phytochemicals acting as enzyme inhibitors and in vivo carbohydrate-digesting enzyme inhibition are required to verify its potential clinical use in diabetes mellitus.
  Pawitra Pulbutr , Sakulrat Rattanakiat , Natnicha Phetsaardeiam , Patcharapa Modtaku , Rattazart Denchai , Achida Jaruchotikamol and Wanwisa Khunawattanakul
  Background and Objective: Streptococcus mutans is a dominant causative pathogen of dental caries, which is a major oral health problem affecting million people worldwide. Derris reticulata is a medicinal plant possessing antimicrobial activity against several Gram-positive pathogenic bacteria. None the less, its effects on growth and cariogenic properties of S. mutans has not been clearly established. This study aimed to investigate the antibacterial and anti cariogenic activities of the D. reticulata ethanolic stem extract. Materials and Methods: The TLC analysis was performed to authenticate the D. reticulata sample. Minimum inhibition concentration and minimum bactericidal concentration were determined by using broth dilution and drop plate methods, respectively. Sucrose dependent and sucrose independent-adherences, biofilm formation and glycolytic pH drop assays were performed to evaluate the anticariogenic activity. Results: The ethanolic stem extract of D. reticulata possessed the antibacterial activity against S. mutans with the MIC and MBC of 0.875±0.250 and 1.750±0.500 mg mL–1, respectively. The extract at the lower concentrations of sub-MIC also had significant inhibitory actions against the cariogenic properties of S. mutans, including surface adherence, biofilm formation and glycolytic acid production. Conclusion: The D. reticulata stem extract had a substantial anticariogenic activities and thus potentially be developed as an oral health care product for dental caries prevention in the near future.
  Sakulrat Rattanakiat , Kanladar Kaewchang , Sofia Thongsang , Achida Jaruchotikamol and Pawitra Pulbutr
  Background and Objective: Antibacterial resistance is one of the top global public health problems. The use of natural substances, which can enhance the antibacterial activity of currently used medications, is a promising alternative to oppose antibacterial resistance. The pharmacological activities of lupinifolin, a prenylated flavanone isolated from stems of Derris reticulata Craib., against growth and biofilm formation of Streptococcus mutans and Staphylococcus aureus have been previously documented. Nonetheless, interactions between lupinifolin and other antibacterial agents have not been determined. This study aimed to investigate the effects of lupinifolin in combinations with some antibacterial agents, specifically ampicillin, cloxacillin or vancomycin, against S. mutans, Methicillin-Sensitive S. aureus (MSSA) and Methicillin-Resistant S. aureus (MRSA). Materials and Methods: The checkerboard assay was performed to determine the antibacterial activity of lupinifolin plus the testing antibacterial agents. The Fractional Inhibitory Concentration Index (FICI) was calculated to indicate the interaction between lupinifolin and the antibacterial agent tested. Results: Lupinifolin exerted the synergistic activity when using in combination with ampicillin or cloxacillin against MSSA with the FICIs of <0.5. The potential synergistic effect was also observed with lupinifolin plus ampicillin or cloxacillin against MRSA. However, the combination of lupinifolin plus vancomycin resulted in no interaction against MRSA. The combined effects of lupinifolin and ampicillin or cloxacillin against S. mutans were somewhat ambiguous with the borderline values of FICI of 0.5156 and 0.5625, respectively. Conclusion: Lupinifolin potentially plays a role as an antibacterial intensifier against some pathogenic gram-positive bacteria, particularly MSSA and MRSA. Nonetheless, further experiments are required to explain the precise mechanism of synergy.
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