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Articles by Abeer El Sayed Elkhamisy
Total Records ( 2 ) for Abeer El Sayed Elkhamisy
  Sherif Salah Mohamed and Abeer El Sayed Elkhamisy
  Background and Objective: A lot of plants have been used traditionally in the treatment diabetic patient for a long time ago. Cordia dichotoma fruits constituents i.e., pulp or seeds comprises of important compounds which have great health benefits. The current study was conducted to investigate the anti-diabetic potential effect of fruits pulp and peel of Cordia dichotoma (C. dichotoma) powder against diabetes mellitus type 2. Materials and Methods: About 24 adult male rats were randomly distributed into to 3 groups each group comprises to 8 rats. The 1st group (I) was fed on the standard normal diet. The 2nd group (II) was given high fat diet (HFD) to induction rats to be obese and after that to be diabetic by long run period and 3rd group (III) was demonstrated HFD+10% of C. dichotoma pulp+peel fiber powder. At the end of the trial, rats were weighted and blood samples were collected for estimating serum biomarkers of diabetes as well as blood glucose, insulin, Leptin and oxidative stress. Results: The results showed that supplemented diet with C. dichotoma powder in 3rd group (III) caused significant increase slightly in body weight gain. Also, The C. dichotoma powder significant decreases in serum levels of blood glucose, AST, ALT, total bilirubin and alkaline phosphatase enzyme in rats. It also had significant increase in serum creatinine. The C. dichotoma powder decreased serum levels of (LDL), triglycerides (TG), total cholesterol (TC) levels, malondialdehyde (MDA) and increased in HDL levels and activity of antioxidant enzymes. Conclusion: Therefore, intake of C. dichotoma pulp+peel fiber powder should be beneficial for the prevention and controlling of diabetic hazards.
  Sherif S. Mohamed and Abeer El Sayed Elkhamisy
  Background and Objective: Garden cress (Lepidium sativum L.) is a fast growing annual plant, the garden cress seed is the herbal edible seeds used in traditional medicine. A number of experimental have been conducted on rats that proven the efficacy of garden cress seeds (GCS) and its protective role in many diseases. Also, the GCS was used in the fortification of different food items. In this study focusing on the potent activity of polyphenol in the natural GCS extract or nanoemulsion of GCS extracts to reduce the oxidative stress in rat induction by paracetamol (PCM) and determined of the potentiality of the two GCS extracts which to be limited. Materials and Methods: The current study evaluated the polyphenol content of the GCS estimated by HPLC in vitro and in vivo determined polyphenols effects in a healthy Wister male rats (32 rats weighing 130±15) which divided into 4 groups to examine antioxidant activity of 2 extracts (Natural and nano) forms. In addition, the best average size of nanoparticles was 198.1±0.553 nm and 90% of the distribution determined by dynamic light scattering (DLS) instrument showed in A1sample nanoemulsion. Results: The findings showed that the natural GCS extract more potential than the nanoemulsion in the antioxidant activity, it may be related to destroyed some of active polyphenols exist naturally in the GCS extract during formulation GCS nanoemulsion by sonication process. Utilizing PCM in over dose was produced N-acetyl-p-benzoquinone imine (NAPQI) compound which exceeded the liver rate of detoxification by GSH, it oxidizes tissue macromolecules such as lipid or -SH group of proteins and alters the homeostasis of calcium after depleting GSH. Conclusion: This study proven that the intake of natural GCS extract as antioxidants is important with the administration PCM notably to avoid side effects of overdose of PCM.
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