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Articles by Abdurrahman Al Diab
Total Records ( 3 ) for Abdurrahman Al Diab
  Abdurrahman Al Diab , S. Qureshi , Mohammad Farhan Qureshi , Viquar Fatima Qureshi and Mohammad Rehan Qureshi
  Behind the alluring fame of established drugs in a magical cure of some types of cancers are myriad toxicities. Hence, it became imperative to search alternative approaches of treatment. Although a large number of papers are published to show that herbs, plant products and their constituents are capable to inhibit the growth of a variety of human colon carcinoma cell lines, there is a gross neglect on an impact of in vivo outcome which show overall effects. The present study on an experimental approach to treatment of Colorectal Cancer (CRC) by herbs, plant products and their constituents was undertaken to review the (1) adverse effects of established drugs used against CRC, (2) herbs, plant products and their constituents as alternatives to established drugs, (3) in vivo studies on herbs, plant products and their ingredients, (4) in vitro studies on herbs, plant products and their ingredients, (5) pros and cons of in vivo and in vitro studies, (6) molecular targets and (7) conclusion. The articles included were peer reviewed English language articles published up to November 2011. These were selected from Pub Med, Pub Med Central, Science Direct, Up-to-date, Med Line, Comprehensive databases, Cochrane library and the internet (Google, Yahoo). The search strategy corresponded with points, 1-6 above. The literature obtained is reviewed. It is suggested that the laboratories working on CRC with in vitro protocol may also undertake confirmatory in vivo experimentation with an application of gene expression profiling using microarray technologies.
  Abdullah Foraih Al-Anazi , Abdurrahman Al Diab , Mohammad Farhan Qureshi , Viquar Fatima Qureshi , Mohammad Rehan Qureshi and S. Qureshi
  Consanguineous marriages are the crucial factors for several genetic disorders and dreadful syndromes which are the bases of morbidity and mortality in the human population. The genetic disorders are linked to abnormalities in either p or q arms of specific chromosomes. However, reports in the literature are not firm on specificity of phenotypic response to the precise genomic region. In view of a paucity of literature on the subject and the controversies arising with respect to the discordance in phenotypic response, this particular case was found interesting for a report in the literature. This is about a baby whose mother was married to her cousin (a consanguineous marriage). The parents had a family history of cerebral palsy and mental retardation. Genetic analysis of the baby showed deletion at 5p14 and the father had translocation between chromosome 5p13 and 10p14 while the mother was genetically normal. The baby was born healthy but had several complications, till he died at the age of 5. The different complications that the baby suffered included: delayed motor activity and developmental disabilities, psychological derrangement, mental retardation, frequent convulsions, microcephali, delayed speech and language development, dysmorphic face, low set ears and hyper reactivity. There was gross discordance in the specific genome region and the phenotypic observations which appears to be due to the interaction between different loci at 5p in addition to epigenetic influence.
  Abdurrahman Al Diab , S. Qureshi , Khalid A. Al Saleh , Farjah H. Al Qahtani , Aamer Aleem , Mohammad Farhan Qureshi , Viquar Fatima Qureshi and Mohammad Rehan Qureshi
  Literature reports suggest a tremendous decline in the global incidence, mortality and morbidity of Colorectal Cancer (CRC) during the post-millennium as compared to the pre-millennium. These developments are attributed to the advancement in technicalities and researches. The status of CRC in the Kingdom of Saudi Arabia (KSA) during the pre-millennium restricted to most of the etiological, histological and epidemiological researches while progress around the world had already begun studies on molecular level. During the third millennium, there are active genome level researches in addition to the development of the link of MicroRNAs with progression of cancer. Although, research on gene expression began in KSA but its involvement in the discovery of newer compounds is still a vision. Furthermore, the researches in KSA lag behind in the new developed era of MicroRNAs. This review on the development of research activities on CRC has revealed that researches in KSA are slow and late but do not lag behind in the global scientific maneuvers taking place in the third millennium.
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