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Articles by Abdullah H. Al-Assaf
Total Records ( 3 ) for Abdullah H. Al-Assaf
  Abdullah H. Al-Assaf
  The aim of this study was to evaluate iron deficiency anemia among adult healthy Saudi males and adult healthy non-pregnant Saudi females in Riyadh City, Saudi Arabia. 234 healthy adults were recruited of which, 102 were females and 132 were males. Male subjects were reclassified to cigarette smokers (n = 52) and non-smokers (n = 80). Anemia was assessed by dietary iron intake, hemoglobin and hematocrit levels. Iron intake was measured by analyzing the intake of three consecutive days. The results showed that iron intake, hemoglobin and hematocrit levels were significantly higher in males compared to females. Mean iron intake of males (13.6±3.1 mg/day) was adequate compared to DRI recommendation. Mean concentrations of hemoglobin (15.89±0.95 g/dL) and hematocrit (47.7±3.6%) for males were normal. Hemoglobin and hematocrit levels were significantly higher in smokers compared to non-smokers, but both were normal, which suggested that iron deficiency anemia is not found among adult Saudi males. Mean iron intake of females (10.2±2.8 mg/day) was inadequate compared to DRI recommendation. Mean hemoglobin level (13.68±0.83 g/gL) and mean hematocrit level (38.9±3.2%) of females were lower than cutoff values for determining iron deficiency anemia. Based on hemoglobin and hematocrit values, 21.6% and 20.6% of female participants, respectively were anemic. Based on iron intake, 95.1% of female participants had intake lower than the recommendation. Results of this study illustrated that iron deficiency anemia is highly prevalent among adult Saudi women in Riyadh City and suggests actions to eradicate iron deficiency anemia. These actions include increasing nutritional awareness and education for the purpose of changing inappropriate consumption patterns as well as fortification of certain foods in combination with additional intakes of iron from supplements.
  Abdullah H. Al-Assaf and Khalid S. Al-Numair
  The aim of this study was to investigate intake of macronutrients and its relation to Body Mass Index (BMI) as well as intake of selected micronutrients in urban and rural healthy adults in Riyadh region-Saudi Arabia. 170 health adults were recruited, 85 of which were urbans and 85 were rurals. Three consecutive days food records were collected and dietary intakes were analyzed by the food processor and other food composition tables. Results showed high intake of macronutrients and prevalence of overweight and obesity in both groups with no significant differences. Subjects of both groups also had high intake of saturated fat. Results also showed inadequate intake of vitamin D, calcium and folate. Few of the participants of both groups had inadequate intake of vitamin C. Intakes of vitamin B1, vitamin B3, iron, vitamin B12, vitamin B6 and vitamin B2 was adequate. No significant differences between the two groups were observed except for vitamin D, calcium and vitamin B2 that their mean intakes were significantly higher in urban group compared to rural group. Mean intake of vitamin B3 was higher in rural group compared to urban group. These findings suggested that overweight and obesity among adult Saudis are due to high intake of macronutrients combined with inadequate intake of some micronutrients, which are results of non-balanced diet and inappropriate consumption patterns. The study also suggests that there is a need of increasing the nutritional education and awareness among adult Saudi males.
  Abdullah H. Al-Assaf
  The present study was designed to investigate the hepatoprotective activity of corosolic acid in CCl4-induced hepatotoxic male albino rats and included an assessment of the antihyperlipidemic properties. Liver necrosis was induced by intraperitoneal injection of CCl4 (1.25 mL/kg b.wt.). Hyperlipidemic agents, such as lipid peroxidation, lipid profile and liver function markers were assessed. The activities of the hepatic marker enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) were increased significantly in CCl4-treated animals. In the serum, increased levels of very low density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C) were observed. Further, an increase in the levels of total cholesterol (TC), phospholipids (PL), triglycerides (TG) and free fatty acids (FFA) in serum and liver were observed in hepatotoxic rats, whereas these hepatic marker enzymes and lipid profiles were significantly protected in corosolic acid pretreated on CCl4-treated animals. These results indicate that the corosolic acid can potentially ameliorate the lipids abnormalities and protect hepatic damage against CCl4-induced hepatotoxicity rats.
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