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Articles by Abdulaziz M. Al-Othman
Total Records ( 4 ) for Abdulaziz M. Al-Othman
  Abdulaziz M. Al-Othman , Fasih Ahmad , Saada Al-Orf , Khalid S. Al-Murshed and Zarina Arif
  In the present study Nigella sativa and Ellataria cardamomum seeds have been studied as inhibitors of oxidative stress caused by oxidized corn oil (having PV 389.8 meq kg-1) in rats. The 70 days feeding male albino rats with experimental diets did not produce significant changes in the body weights, organ weights and food intake of different groups. Increased lipooxidative damage was noticed in oxidized oil fed rats. Oxidized oil diet supplemented with cardamom or N. sativa had marked reduction in RBC hemolysis and plasma AST/ALT activity. The formation of thiobarbituric acid reactive substances were lowest in rats fed N. sativa supplemented diet. Reduced glutathione of liver and kidney were significantly raised after the addition of cardamom/N. sativa to the diets compared to oxidized oil fed rats (Group F). But heart reduced glutathione showed a significant increase as compared to oxidized oil fed group only after the supplementation of N. sativa to the diet. These data indicates that N. sativa or cardamom supplementation improves the overall antioxidant protection capacity of the body.
  Mohammed A. Alsaif , Latifa K. Khan , Adel A.H. Alhamdan , Saada M. Alorf , Sawsan H. Harfi , Abdulaziz M. Al-Othman and Zarina Arif
  The aim of present study to evaluate the effect of dates, gahwa and their combination on lipid metabolism in hypercholesterolemic hamsters. The increase intake of dates and gahwa (Arabian coffee) along with a high cholesterol diet in Saudi population as well as increased incidence of cardiovascular disease (CVD) has raised a concern about the effects of the Saudi diet on CVD risk. Golden Syrian hamsters were divided into six groups (six animals in each) as follows: 1) control (chow), 2) Dates-diet (50% date pulp with chow), 3) Dates-diet + gahwa (replaced with drinking water), 4) cholesterol-diet (1% cholesterol in chow), 5) dates-diet + 1% cholesterol, 6) Dates-diet + gahwa + 1% cholesterol. All the above dietary preparations were made every week and supplemented for 13 consecutive weeks. Plasma lipid profile including total cholesterol, triglycerides (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) were estimated. Total cholesterol and TC were estimated in liver, heart and kidney tissues. The high cholesterol-diet caused significant increase in body and organs (liver and kidney) weights as compared to controls. Dates-diet, significantly reduced the body and liver weight that increased by the high cholesterol-diet. Plasma lipids were significantly elevated by high cholesterol-diet supplementation and this increase was significantly decreased by the dates-diet. However, hepatic TC levels further increased when dates were combined with high cholesterol-diet supplementation. Gahwa intake either with dates alone or with high cholesterol-diet was not induced any significant changes in lipid parameters. In conclusion, the dates lowering effects on body weights and plasma lipid profile shows its beneficial affects against atherosclerosis development in humans. Further investigations required for find out its potential constituents that affecting the CVD risk.
  Mohammed A. Alsaif , Latifa K. Khan , Adel A.H. Alhamdan , Saada M. Alorf , Abdulaziz M. Al-Othman and Rabab J. Makki
  This study was designed to investigate the dietary components which are likely to contribute to osteoporosis in postmenopausal Saudi women. In the present study, 36 osteoporotic postmenopausal and 25 healthy postmenopausal women as cases and controls respectively were selected from Armed Forces Hospital, Riyadh, Saudi Arabia. The study has designed to collect the data about the general characteristics (age, marital status, education, number of pregnancies, activity level, income and housing), anthropometric measurements, medical history and dietary intake by using both the methods (24 h recall, food frequency questionnaire). Serum samples were analyzed for calcium, phosphorus, vitamin D and Para Thyroid Hormone (PTH) and they were correlated with Bone Mineral Density (BMD). Food intake items were correlated with hip, neck and spin BMD. In results, cases found significantly older than controls and had history of bone fractures. Cases were consumed significantly less dietary calcium than controls. Serum parameters did not show any significant differences. However significant correlation was found between serum level of PTH and calcium with BMD of spine and right neck femur respectively. Banana and Mataziz (locally prepared dish with vegetables) showed positive correlation with hip BMD. A negative significant correlation was found between Arabian coffee and right neck femur BMD. In conclusion, Saudi women require encouragement to consume adequate amounts of calcium, fruits and vegetables in combination with maintaining a daily physical activity and space in child birth.
  Adel A. Al-Hamdan , Rabba H. Al-Huthail , Mohamed A. Alsaif , Abdulaziz M. Al-Othman , May N. Al-Muammer , Saada M. Al-Orf , Abdallah A. Saeed and Badreldin A. Mohamed
  To study the effect of weight-reduction diet (WRD) on serum high sensitivity C-reactive protein (hs-CRP) level in obese-adult subjects admitted to Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia. Fifty three subjects with body mass index (BMI) ≥ 30 kg m-2 were included in the study. They were placed on energy-restricted diet for 12 weeks. Diet history and food-frequency questionnaire were filled before starting the WRD. Anthropometric measurements [weight, height, BMI and waist circumference (WC)] were taken and blood samples were collected to analyze hs-CRP, total cholesterol, triglyceride, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol before and at the end of the WRD. There is a significant reduction in BMI and WC after applying the WRD program. In addition, hs-CRP level, triglyceride and total cholesterol were significantly reduced after applying the WRD. A significant positive correlation was noted between serum hs-CRP level and measures of adiposity, such as BMI and WC. hs-CRP level is influenced by WC and by BMI in obese-adult subjects and that the WRD decreases serum level of hs-CRP.
 
 
 
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