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Articles by Abdolvahab Alborzi
Total Records ( 4 ) for Abdolvahab Alborzi
  Aziz Japoni , Mehdi Kalani , Abdolvahab Alborzi , Sara Japoni and Noradin Rafaatpour
  Problem statement: Due to continuous changes in the frequencies and antibacterial susceptibility patterns of nosocomial pathogens, periodical surveillance of these fluctuations could help the clinicians to treat hospitalized patients more efficiently whenever empirical therapies need to be considered. This study was conducted to compare the prevalence of the bacteria recovered from bloodstream samples by Bactec 9240, over the two periods of 2001-2004 and 2005-2008 and to evaluate their antibacterial susceptibility patterns. Approach: Totally, 3622 culture positive blood samples were analyzed over the periods. Antibacterial susceptibility patterns of the isolates were determined by standard disk diffusion (Kirby-Bauer) method. The data were compared in terms of quantity and quality of the pathogens and based on their distributions in three main wards. Results: Changes were observed in bacterial composition and frequencies of them, between the two periods. Compared with the first pried, increased frequencies of antibiotic resistant bacteria such as S. aureus, enterococci, acintobacter and pseudomonas were noticed in the second period. Most patients were admitted to pediatrics, followed by adults and neonates wards. Increased antibiotic resistance of the majority of the bacteria in the second period indicates the decreased efficacy of corresponding antibiotics. However, overall efficacy of some antibiotics such as ciprofloxacin and amikacin against Gram positive bacteria preserved. Conclusion: Trend of composition of the bacteria from first to second period could suggest the domination of antibiotic resistant bacteria over the sensitive ones. Appropriate strategies including strict control measures and rational prescription of the effective antibiotics may retard the trend accordingly. Vancomycin and imipenem were the most active antibiotics against Gram positive and negative bacteria. Combination of these two antibiotics is highly recommended for empirical therapy.
  Aziz Japoni , Shohreh Farshad , Abdolvahab Alborzi , Mehdi Kalani , Nouradin Rafaatpour , Barat Oboodi and Bahman Pourabbas

This study was conducted to determine the prevalence of bacteria recovered from bloodstream samples by Bactec 9240 at our hospital wards and to evaluate their antibacterial susceptibility patterns. During January 2001 through December 2004, 9407 referred blood samples in Bactec bottles from admitted patients at three main wards, neonates, pediatrics and adults at Nemazee Hospital, affiliated to Shiraz University of Medical Sciences in Shiraz were processed. Positive cultures were purified and identified according to standard methods. Sensitivity of bacteria to different antibiotics was determined by Kirby-Bauer disk diffusion method. Staphylococcus aureus 132(25%), Escherichia coli 64(12.1%) and Pseudomonas aeruginosa 52(9.8%) were the most pathogenic bacteria which were recovered from the blood samples. Pathogenic microorganisms were isolated from blood samples of 305 (57.8%) at pediatrics, from 181 (34.2%) at adults and from 42 (8%) at neonates wards. The highest antibiotics activities against gram positive isolates observed for vancomycin (98.4%), chloramphenicol (86.4%) and ciprofloxacin (77.4%), while in gram negative bacteria imipenem (96.1%), ciprofloxacin (83%) and amikacin (77.9%), were effective antibiotics. Frequency of isolated bacteria at pediatrics compared to adults and neonates wards were approximately two and seven folds high, respectively which indicates special attention should be paid to pediatrics patients both in prevention and treatment aspects. Vancomycin and imipenim are the effective antibiotics and could cover majority of gram positive and negative bacteria. Therefore, combined administrations of these antibiotics seems mandatory for empirical therapy.

  Shohreh Farshad , Abdolvahab Alborzi and Amin Abbasian
  To evaluate the association of virulence genes CagA, VacA and UreAB of H. pylori with the development of different gastric disorders, polymerase chain reaction was performed on H. pylori organisms isolated from biopsy samples of stomach of patients with ulcerative disease and nonulcerative disease. The difference between the groups was statistically significant (p<0.05) only for VacA gene. We detected 8 phenotypes, characterized as CagA+-VacA+-UreAB+ (phe 1), CagA¯-VacA¯-UreAB¯ (phe 2), CagA+-VacA+- UreAB¯ (phe 3), CagA+-VacA¯-UreAB+ (phe 4), CagA¯-VacA+-UreAB+ (phe 5), CagA+-VacA---UreAB¯ (phe 6), CagA¯-VacA+-UreAB¯ (phe 7), CagAVacA¯-UreAB+ (phe 8). The prevalence of phenotype 1 was significantly higher in the patients with UD than that in the patients with NUD (p<0.05). These results suggest that in the population under our study, being infected by a H. pylori strain with the genotype CagA+-VacA+-UreAB+ may be associated with an increased risk of acquiring an ulcer disease.
  Mazyar Ziyaeyan , Bahman Pourabbas , Abdolvahab Alborzi and Jalal Mardaneh
  The present study was conducted to determine the prevalence of antibody against the human parvovirus B19 among 5-25 year old individuals in Shiraz, southern Iran. Serum samples from 908 individuals (505 female and 403 male) were studied. The patients were categorized into seven age groups. The IgG anti-parvovirus B19 was determined by the commercial ELISA kit. Anti-parvovirus B19 IgG was found in 70.09% of the females and 60.04% of the males in this study. In general, 65.63% of the study population had IgG against parvovirus B19. Results from this study have show that the prevalence of parvovirus infection is found to be higher in females than males and in the majority of cases, infection with parvovirus occurs in the pre-school age period. These findings may differ from what is found other countries.
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