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Articles by Abdolhosein Shamshirgar-Zadeh
Total Records ( 2 ) for Abdolhosein Shamshirgar-Zadeh
  Maysam Mard-Soltani , Mahnnaz Kesmati , Lotfolah Khajehpour , Abdolrahman Rasekh and Abdolhosein Shamshirgar-Zadeh
  Many studies have shown that anxiety-like behaviors are influenced by peripheral and central parameters including hormones and neurotransmitters in the different areas of Central Nervous System (CNS). Many investigations have proven the anxiolytic effect of androgens in different methods. Also, there are many reports about the modulating role of the amygdala complex, especially Basolateral Amygdala (BLA), through adrenergic system on anxiety. Among various types and subtypes of adrenergic receptors, β-1 adrenoceptors (β-1 ARs) of BLA account for the anxiety. The purpose of this study was to examine the relationship between testosterone and β-1 ARs in the BLA as an anxiety regulating key of CNS. Using Elevated plus Maze (EPM), the anxiety-like behaviors of four groups of intact adult male Wistar rat were assessed in the presence of different doses of testosterone (0, 20, 30 and 40 mg kg-1, Intraperitoneal (i.p.). Then, the effects of intra-BLA microinjection of different doses of betaxolol, a selective β-1 ARs antagonist, (0, 0.025, 0.1 and 0.4 μg rat-1), were evaluated in the other four groups. Finally, the interaction between the ineffective dose of testosterone via i.p. and betaxolol via intra-BLA was investigated. The results obtained revealed that testosterone (i.p.) and betaxolol (intra-BLA) alone had anxiolytic effects on the male Wistar rats in a dose-dependent manner. Our findings also showed that the anxiolytic effects of testosterone (i.p.) were reinforced by the intra-BLA injection of betaxolol. Co-administration betaxolol and testosterone also showed the synergistic actions on anxiolytic effects in the adult male Wistar rats. Our results interestingly proposed that the interaction between testosterone and β-1 ARs is in part related to common mechanism and other neurotransmitters include gamma-aminobutyric acid (GABA) and serotonin.
  Maysam Mard-Soltani , Mohammad Reza Dayer , Abdolhosein Shamshirgar-Zadeh , Hamid Ali-Bahar and Zahra Nasirbagheban
  Diabetes mellitus as a heterogeneous disease along with hyperglycemia causes quite many acute and chronic complications including cardiovascular complication. Cardiovascular complications are caused because of numerous factors such as increased Fasting Blood Sugar (FBS), Triglyceride (TG), hypercholesterolemia, hypercoagulable state and a change in balancing lipoproteins including Low Density Lipoproteins (LDL) and High Density Lipoproteins (HDL). Because of probable role of HDL in prevention of cardiovascular complications and its antithrombotic role in diabetics, we have studied lipoproteins and HDL in particular, effect on coagulation parameters which may potentially lead to cardiovascular complications in type 2 diabetics. In this study, 60 type 2 diabetics in early stage of diabetes were compared statistically with 50 healthy subjects in terms of biochemical factors of: FBS, TG, VLDL, LDL, coagulation parameters of: Partial thromboplastin time (PT), Activated Partial Thromboplastin Time (APTT), specific activity of coagulation factors and then the correlation between the biochemical and coagulation parameters was measured using Pearson’s correlation coefficient. Our findings showed that FBS, TG, VLDL and coagulation factors of: II, IX, X, XI in diabetics had increased significantly compared with healthy subjects. They also indicated that APTT and therefore, the intrinsic coagulation pathway in diabetics prolonged in comparison with the healthy individuals. There were no other significant differences in the measured parameters between two groups. On the other hand, by studying biochemical and coagulation factors, it was shown that there was a positive significant correlation among FBS, cholesterol and HDL with the coagulation factors of II, V, IX, X, XI. There was, interestingly, a negative significant correlation between HDL and APTT. The observed correlation between coagulation factors and HDL, regardless of the no significant difference of HDL in the two groups, shows that probably the hypercoagulable state as a result of hyperglycemia led to plasma increase of HDL. In other words, HDL, probably, because of hypercoagulable state, intended to remove their destructive effects of hypercoagulable state and then correlated with them.
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