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Articles by Abdel-Tawab H. Mossa
Total Records ( 5 ) for Abdel-Tawab H. Mossa
  Mamdouh A. Marzouk , Abdel-Tawab H. Mossa and Farid S. Sabra
  World Health Organization emphasized the necessity of evaluating toxic hazard of the formulated pesticides. So, in current study, the genotoxic and cytotoxic potential of technical and formulated tribenuron-methyl herbicide were investigated in male rat bone-marrow cells, using the Structural Chromosomal Aberration (SCA) and micronucleus (MN) test systems. Technical and formulated tribenuron-methyl were administrated to rats as single or repeated oral doses of 5 (NOAEL), 25, 50 and 100 mg kg-1 b.wt. for 21 days at 48 h intervals. Results showed that repetitive dose of formulated tribenuron-methyl (100 mg a.i. kg-1 b.wt.) induced significant decrease in the mitotic activity. After repetitive doses, the frequency of total chromosomal aberrations was statistically significant (p≤0.05-0.01) at two higher doses, 50 and 100 mg a.i. kg-1 b.wt. of formulated tribenuron-methyl as well as significant increase (p≤0.05) at high dose (100 mg a.i. kg-1 b.wt.) of technical tribenuron-methyl. The frequency of MN was statistically significant at two higher doses, 50 (p≤0.05) and 100 (p≤0.01) mg a.i. kg-1 b.wt. of formulated tribenuron-methyl. Our results reveal that tribenuron-methyl has a clastogenic/genotoxic potential as measured by the bone marrow CA and MN tests in rats. The partial differences of the genotoxic effects obtained with pure and commercial tribenuron-methyl indicate that commercial formulations may contain additional hazardous compounds. Therefore, it is important in assessing the real human hazard from pesticides to investigate not only the active principle but also the commercial formulations used in agriculture.
  Moustafa A. Abbassy and Abdel-Tawab H. Mossa
  Pesticide formulations are complex mixtures and the toxicity information on active ingredients alone is not sufficient to evaluate the risk of adverse health effects of commercial pesticides. So, the present work was conducted to study the haemato-biochemical effects of technical and formulated cypermethrin (25.0 mg kg-1 b.wt.) and deltamethrin (1.70 mg kg-1 b.wt.), in male rats given repetitive oral doses for 90 consecutive days. There was high significant decrease (p≤0.01) in body weight gain of cypermethrin and significant decrease (p≤0.05) in deltamethrin treated rats. The relative liver and kidney weights were significantly change in the treatments of formulated and technical cypermethrin and deltamethrin compared to the control. Deltamethrin as technical or formulated form caused significant changes (p≤0.01) in haemoglobin, packed cell value and Red Blood Cell (RBC), while formulated and technical cypermethrin caused significant decrease (p≤0.05) in PCV % and formulated cypermethrin induced significant decrease (p≤0.01) in White Blood Cell (WBC) compared to control value. Treatments with formulated and technical cypermethrin and deltamethrin caused significant increase (p≤0.01) in serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) activities and formulated cypermethrin seemed to induce higher AST elevation (200.67 IU L-1) and formulated deltamethrin induce higher ALT elevation (105.07 IU L-1) as compared with the untreated group (21.30 and 25.50 IU L-1, respectively). Technical cypermethrin and deltamethrin caused highly significant (p≤0.01) decreased in serum glucose. On the other hand all of the tested insecticides induced significant decreases (p≤0.05) in serum total protein and increase (p≤0.05-0.01) in creatinine and uric acid concentrations. The partial differences of hematological and biochemical effects obtained with pure and commercial deltamethrin and cypermethrin indicate that commercial formulations may contain additional hazardous compounds. Therefore, it is important in assessing the real human hazard from pesticides to investigate not only the active principle but also the commercial formulations used in agriculture.
  Abdel-Tawab H. Mossa , Amel A. Refaie and Amal Ramadan
  The present study was designed to evaluate the effect of exposure to mixture of four Organophosphate insecticides (OPIs) at dose equaled to No Observed Adverse Effect Level (NOAEL) for 28 day on liver of male rats and their attenuation by vitamin C (V.C). Rats were divided into four groups of six each: control, OPIs, OPIs+V.C and V.C group. The activities of serum aspartate aminotransferase (AST), Alanine Transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were statistically (p≤0.01) increased, while the activity of cholinesterase (ChE) was decreased in rats exposed to OPIs. Supplementation of V.C was mitigating the adverse effects of OPIs but the increased were still significantly (p≤0.05). Body weight and total protein concentration were statistically (p≤0.05) decreased, while relative liver weight was statistically (p≤0.05) increased in OPIs-treated group. In addition, administration of OPIs resulted in damage of liver structures. Combination therapy with V.C significantly (p≤0.05) restored these alterations to within the normal limits and prevents disruptions of liver structures. According to these results, it is suggested that exposure to multi-chemical with a common mechanism of toxicity might cause hazardous effects at NOAEL levels to non-target organisms, including humans.
  Abdel-Tawab H. Mossa and Moustafa A. Abbassy
  Pesticides formulations are complex mixtures and the toxicity information on active ingredients alone is not sufficient to evaluate the risk of adverse health effects of commercial pesticides. So the present study was designed to investigate the adverse effects of exposure to formulated chlorpyrifos-ethyl (9.60 mg kg-1 b.wt.), chlorpyrifos-methyl (300 mg kg-1 b.wt.) and methomyl (1.70 mg kg-1 b.wt.) on some haematological and biochemical parameters of male rats given repetitive oral doses for 90 consecutive days. There was significant decrease in body weight gain of chlorpyrifos-ethyl, chlorpyrifos-methyl and methomyl and increase in relative liver and kidney weights of chlorpyrifos-ethyl and chlorpyrifos-methyl treated rats. Chlorpyrifos-methyl caused significant decrease in Hb conc. Haematocrit value (PCV, %) and Red Blood Cells (RCBs) counts, while chlorpyrifos-ethyl and methomyl caused significant decrease in PCV% and White Blood Cells (WBCs) counts. All of the tested insecticides increased significantly serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) activities and decreased significantly the total protein level. In addition, the tested insecticides caused significant increase in serum uric acid and creatinine. We can conclude that both technical and formulated methomyl and chlorpyrifos-ethyl and its methyl analogues caused significant alteration on hematological and biochemical parameter of mal rats. The effects of commercial form of tested insecticides were more pronounced than its technical form.
  Tarek M. Heikal , Abdel-Tawab H. Mossa , Azza W. Ibrahim and Hala F. Abdel-Hamid
  Pesticides have contributed for many public health hazards in man including infertility. So, the present study aimed to assess the protective role of green tea extract (GT) against the possibility of reproductive toxicity resulting from chlorpyrifos (CPF), cyromazine (Cyr) and their combination exposure in mature male Wistar rats. Rats were administered CPF (5.4 mg kg-1 b.wt., 1/25 LD50), Cyr (135.48 mg kg-1 b.wt., 1/25 LD50), CPF+Cyr, GT (1.5% w/v in water) as the only drinking fluid, CPF+GT, Cyr+GT and CPF+Cyr+GT daily via gavage for 70 days to complete the spermatogenic cycle. The results revealed that exposure to CPF, Cyr and CPF+Cyr significantly decreased the fertility index, weights of sexual organs (testes, seminal vesicles, epidermis and prostate gland), sperm characteristics (motility and count) as well as serum testosterone level, while increased sperm abnormality. In addition, the testicular tissue level of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) enzymes were significantly decreased while increased the level of testicular tissue lipid peroxidation (LPO) compared with the control group. The testicular histopathological lesions were characterized by moderate to severe degenerative changes of seminiferous tubules and incomplete arrest of spermatogenesis. Co-administration of GT to treated-animals alleviates the reproductive toxicity and testicular oxidative damage. In conclusion, the use of green tea extract appeared to be beneficial in attenuating and improving the testicular damage and reproductive toxicity sustained by insecticide exposure in male rats.
 
 
 
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