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Articles by Abdel-Tawab H. Mossa
Total Records ( 2 ) for Abdel-Tawab H. Mossa
  Abdel-Tawab H. Mossa , Tarek M. Heikal , Samia M.M. Mohafrash and Amel A. Refaie
  The present experiment was designed to evaluate the oxidative damage and hepatotoxicity resulting from Pirimiphos-Methyl (PM) exposure as well as the hepatoprotective potential of Origanum majorana L. leaves extract in male mice. The results revealed that Majorana leaves extract exhibited antioxidant capacity manifested by inhibitory effects on DPPH, ABTS, hydroxyl radical and reducing power in vitro. Male mice were divided into six groups of six mice each: Control group (I) extract groups (II and III) received an extract at doses of 150 and 300 mg kg-1 b.wt.; PM group (IV) received PM (12.0 mg kg-1 b.wt., 1/10 LD50) in corn oil; groups (V and VI) received PM along with the two doses of extracts. All the applications were administered via oral route for 28 consecutive days. Exposure of mice to PM caused significant changes in body and relative liver weights as well as significant increases in the activity of serum enzymes alanine aminotransferases (ALT), aspartate aminotransferases (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Also, PM induced significant decreases in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and in the content of glutathione reduced (GSH), however, induced a significant increase in the level of hepatic lipid peroxidation (LPO) accompanied by histopathological alterations in liver of male mice. Co-administration of O. majorana extract to PM ameliorated the above-mentioned parameters. The ultimate effect was achieved by the highest dose of the extract. It could be concluded that PM induced oxidative damage and liver injury in male mice. However, co-administration of O. majorana leaves extract attenuated the harmful effects of PM which may be attributed to its antioxidant potential. Results indicated that O. majorana leaves could be used for therapeutic option against hepatic injuries resulting from pesticide intoxication.
  Eman S. Swelam , Ibrahim S. Abdallah and Abdel-Tawab H. Mossa
  Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg L–1 (2.0 mg kg–1 b.wt.), zinc at concentration 227 mg L–1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kg–1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.
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