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Articles by Abd El-Galil E. Amr
Total Records ( 3 ) for Abd El-Galil E. Amr
  Abdullah M. Al-Mohizea , Abd El-Galil E. Amr and Mohamed A. Al-Omar
  Problem statement: The role of 5-HT has been investigated in many behavioral activities. Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels, habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulation and water consumption. Approach: The metabolic interaction between serotonin (5-hydroxytrptamine) and indole-3-aldehyde and xanthine via aldehyde oxidase (EC 1.2.3.1) and xanthine oxidase (EC 1.1.3.22), respectively, were studied in liver tissue homogenate of Dunkin-Hartley guinea pigs by following the decrease in substrate concentration using spectrophotometer. Homogenates of liver were incubated with indole-3-aldehyde in the presence and absence of serotonin or (chlorpromazine and allopurinol a potent and selective inhibitors for aldehyde oxidase and xanthine oxidase, respectively). Oxidation of indole-3-aldehyde to indole-3-acetic acid was reduced up to 63.2% in the presence of serotonin (100 μM), while oxidation of xanthine to uric acid was reduced up to 51.6% under the same conditions. Results: In comparison, incubation of the substrates with their specific inhibitors (100 μM of chlorpromazine and 100 μM allopurinol) give almost complete inhibition. These results demonstrate that in the guinea pig liver a metabolic interaction between serotonin and indole-3-aldehyde or xanthine via molybdenum hydroxylases system may take place in liver, which is the main tissue for xenobiotics detoxification. Conclusion: The overall conclusion from this research is that serotonin could be a protector for neurons and other tissue from the insult of oxidation of aldehydes and xanthines by molybdenum hydroxylases.
  Salwa F. Mohamed , Alhusain A. Ibrahiem , Abd El-Galil E. Amr and Mohamed M. Abdalla
  A series of several substituted pyrazole and pyrimidine derivatives were synthesized based on 1-(3-aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one (3) as starting material, which was obtained from the reaction of 3-indolaldehyde with 3-aminoacetophenone. Treatment of chalcone 3 with hydrazine hydrate or phenylhydrazine gave the corresponding pyrazole derivatives 4 and 5. Cyclization of 3 with hydroxylamine hydrochloride, thiosemicarbazide or hydrazine hydrate/acetic acid afforded the corresponding cyclized products 6-8, respectively. The reaction of 3 with guanidine hydrochloride gave the corresponding aminopyrimidine derivative 9, which was reacted with 1, 1-carbonyldiimidazole or p-flourobenzaldehyde afforded compounds 10 and 11. Condensation of 3 with urea in the presence of sodium ethoxide gave pyrimidinone derivative 12. Finally, reaction of 9 with 1, 3-indanedione afforded compound 13, which was treated with cyclopentanone or 3, 4-dimethoxybenzaldehyde to give the corresponding arylidine derivatives 14 and 15. The synthesized derivatives were tested against SARS CoV 3C-like protease and were founded active.
  Alhussein A. Ibrahim , Mohamed F. El-Shehry , Hanaa M. Hosni , Abd El-Galil E. Amr and Mohamed M. Abdalla
  A series of pyrrolo[2,3-d]pyrimidine, pyrrolotriazolopyrimidine and pyrrolotetrazolopyrimidine derivatives 2-13 were synthesized using 2-amino-1-(3-(trifluoromethyl)phenyl)-4,5-bis (4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile 1 as starting material. The biological rational upon which the newly synthesized compounds was built was their structural similarity with some pyrrole derivatives that having antimelanomal, anti-tetrahymena and some kinases inhibitor activities. Some of the newly synthesized compounds showed antimelanomal, anti-tetrahymena and some kinases inhibitor activities of the 124 kinases panel.
 
 
 
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