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Articles by Abd El-Galil E Amr
Total Records ( 2 ) for Abd El-Galil E Amr
  Abd El-Galil E Amr , Mohamed A. Al- Omar and Mohamed M. Abdalla
  A series of synthesized 2,6-bis(tetracarboxamide)-pyridine and macrocyclic tripeptide derivatives 1-6 were previously prepared and screened as antimicrobial, anti-inflammatory and anticancer agents. The compounds for evaluation of analgesic, anticonvulsant and antiparkinsonian activities were used. Analgesic activities of selected compounds determined by hot plate assay, all tested compounds showed this property. Anticonvulsant activities of selected compounds measured their abilities to antagonize yohimbine-induced clonic seizure, all tested compounds showed this property. The antiparkinsonian activity measured by the ability of compounds to protect animals against the parkinsonian like signs induced by agonists, all tested compounds showed this property. All tested compounds showed analgesic, antipakinsonian and anticonvulsant activities and the order for these activities were 5b, 6a, 3, 5a, 5c, 4, 6c, 2, 6b and 1.
  Abd El-Galil E Amr , Mohamed A. Al- Omar and Mohamed M. Abdalla
  A series of chiral linear and macrocyclic bridged pyridines (1-8) has been prepared starting from pyridine-2,6-dicarbonyl dichloride and they screened as antimicrobial agents before. Screening of the compounds for their Inhibition of type A and type B monoamine oxidase activities in mitochondria preparation revealed that the tested compounds showed selective inhibition of type A monoamine oxidase activities in the following order 4a, 6, 5a, 3, 4b, 5b, 1, 4c, 7, 8 and 2, this confirmed by the in vivo tryptamine seizure potentiation model in rats. The tested compounds showed in vivo good pharmacokinetic and pharmacodynamic profiles.
 
 
 
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