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Articles by Abbas Shafiee
Total Records ( 4 ) for Abbas Shafiee
  Sara Rasoul-Amini , Ali Khalaj , Abbas Shafiee , Mohsen Daneshtalab , Armin Madadkar-Sobhani , Shamileh Fouladdel and Ebrahim Azizi
  New cytotoxic quinoline derivatives were designed, synthesized and evaluated in vitro as anti-tumor agents in comparison to available drugs including Adriamycin (ADR), Vincristin (VCR), Etoposide (VP16) and Tamoxifen (TAM). Human breast cancer T47D cells were cultured in RPMI 1640 complete culture medium and exposed for 48 h to different concentrations of newly synthesized quinoline derivatives [SRA-HX-(1-3) and SRA-BQ] and also to ADR, VCR, VP16 and TAM. A dose-dependent decrease in cell proliferation was observed following exposure to almost all synthesized quinolines. The highest cytotoxicity was seen at 1x10-4M concentration of SRA-HX-3 that was near to growth inhibitory effect of ADR (1x10-6M) and significantly (p<0.002) greater than VCR, VP16 and TAM (each at 1x10-6M). The other 3 compounds (1x10-4M) had similar activity to VCR that was less than ADR and significantly (p<0.002) greater than VP16 and TAM. Therefore, new cytotoxic quinolines are potentially good candidates for further investigation as anti-tumor compounds.
  Mohammad Sharifzadeh , Kurdistan Sharifzadeh , Mahnaz Khanavi , Abbas Hadjiakhoondi and Abbas Shafiee
  The aim of this study was to evaluate the anti-inflammatory activities of total methanolic extracts isolated from aerial parts of Stachys persica and Stachys setifera. The anti-inflammatory properties of the extracts were assessed by using two well-characterized inflammatory models, carrageenan-induced paw edema and formalin test in rats and mice. Intraperitoneal injections of the extracts 60 min before carrageenan injection caused significant inhibition on carrageenan-induced paw edema over the dose range 50-200 mg kg-1. The extract of Stachys persica showed more inhibitory effect especially with higher doses (100 and 200 mg kg-1). In the formalin test, intraperitoneal injections of different doses (50, 100 and 200 mg kg-1) of either Stachys persica or Stachys setifera 30 min before formalin injection did not show any inhibitory effects in the first phase (0-10 min) of the formalin-induced pain, but all three doses of the extracts revealed a significant (p<0.01) blockade of the second phase (20-30 min) nociception. The anti-inflammatory properties of both extracts were comparable with indomethacin as a potent non-steroidal anti-inflammatory drug. In conclusion, the present findings provide further evidences for inhibitory effects of Stachys persica and Stachys setifera in inflammatory processes via possible interactions with cyclooxygenase products.
  Mohsen Amini , Morteza Pirali-Hamedani , Hossein Ali Ebrahimi , Majid Darabi and Abbas Shafiee
  A HPLC method for determination of rofecoxib in human serum was presented. The method is based on pre-column derivatization of analyte to a phenanthrene derivative of drug. Rofecoxib and internal standard were extracted from serum using liquid-liquid extraction. Upon exposure to UV light, drug was found to undergo a phtocyclization reaction giving a species with high absorbance. Validation of the method has been studied in the concentration range of 2-100 ng mL-1.
  Naghmeh Hajarolasvadi , Mohammad J. Zamani, , Parisa Sarkhail , Reza Khorasani , Masoomeh Mohajer , Gholamreza Amin , Abbas Shafiee , Mohammad Sharifzadeh and Mohammad Abdollahi
  The objective of the present study was to evaluate the anti-inflammatory and analgesic activities of the crude and fractioned extracts (ether, ethyl acetate, n-butanol and water) of Phlomis anisodonta (Lamiaceae) in the models of carrageenan-induced paw edema and acetic acid-induced writhing in mice. Dried powdered material from the aerial parts of Phlomis anisodonta was extracted with methanol (80%) twice. The methanol extract was separated into four fractions: after drying the methanol extract, the solid residue was dissolved in water and the water-soluble portion was successively partitioned to produce the above-mentioned fractions. The total extract, ether fraction and ethyl acetate fractions significantly reduced the number of writhings compared to the control group. Water and n-butanol fractions showed no analgesic activity. Neither the total extract nor four fractions were more effective than indomethacin in acetic acid-induced test. In carrageenan-induced inflammation test, only water and ethyl acetate fractions showed antiinflammatory activity compared to the control group. The total extract, n-butanol and ether fractions showed no antiinflammatory activity. Neither the total extract nor four fractions were more effective than indomethacin. Different types of glycosides found in the genus Phlomis could be responsible for observed effects. Variations in antiinflammatory and analgesic effects of different fractions of this plant might be attributed to the fact that different fractions of P. anisodonta contain active compounds in variable ratios and activities. A comprehensive analysis for determination and quantification of these compounds is required).
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