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Articles by A.Z. Hassan
Total Records ( 2 ) for A.Z. Hassan
  Gabriel Ochube , A.Z. Hassan , U.S . Abdullahi and M.Y. Fatihu
  Daily body and hematological parameters were recorded following an attempt to manage clinical compound fractures of 18 healthy Kano Brown goats using Sherman’s compression plates via internal reduction. The hematological parameters before during and after surgery were determined by full blood count. The results showed that inflammatory cells such as nuetrophils, esinophils and lymphocytes were at their peak when the implants were in the body of the animals. There was significant increase (p<0.05) in total leukocyte counts a week after surgery. This increase could be attributed to the presence of bone plates. Other parameters such as body temperature, pulse rate, respiratory rate were recorded for 160 days. Body temperature, respiratory and pulse dropped to normal physiologic rates after implants were removed and healing was complete. It was concluded that implants plays important role in stimulating leukocytosis.
  S.A. Babalola , M.M. Suleiman , A.Z. Hassan and D.A.Y. Adawa
  This study evaluates the methanolic crude extract of Datura metel L. seeds (family Solanaceae) as a potential oral anaesthetic in dogs. Following the oral acute toxicity study to determine the median Lethal Dose (LD50) of the extract in twelve (12) mice, the extract was relatively safe since when administered at the highest dose (5,000 mg kg-1) no sign of toxicity and no death was recorded. In the in vivo sedative and anaesthetic study of the effect of Datura metel L. in this research, the observed pharmacological effect of the extract administered orally to 5 dogs separately at a dose rate of 0.6, 1.2, 1.5, 2 and 2.4 g kg-1, respectively during establishment of a suitable pilot oral anaesthetic doses, showed a graded dose response relationship. The extract at an oral dose of 2.4 g kg-1 induced surgical anaesthesia in dogs with increased heart and respiratory rates (107-205 bpm and 36.33-41.33 cpm), respectively, normal rectal temperature (37.83°C), adequate tissue perfusion, good muscle relaxation but poor analgesia, loss of anal sphincter tone and loss of pupillary reflex. The dogs recovered without any complications. This study has shown that the seed extract of Datura metel L. is relatively safe, induced sleep similar to that of thiopentone sodium anaesthesia with good anaesthetic indices at the oral dose rate of 2.4 g kg-1 in dogs.
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