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Articles by A.Y. Al-Taher
Total Records ( 5 ) for A.Y. Al-Taher
  A.Y. Al-Taher
  The Pharmacokinetic characters of cefquinome were studied in camels following single intramuscular administration of 1 mg kg-1 b.wt. Cefquinome concentrations in serum were determined by microbiological assay using Micrococcus luteus (ATCC 9341) as test organism. After intramuscular administration, the mean peak serum Concentrations (Cmax) was 1.23 μg mL-1 and achieved after (tmax) 4.25 h. The absorption half life (tl/2(ab)) was 4.35 h and the elimination half-life (tl/2(el)) was 10.24 h. The Mean Residence Time (MRT) was 16.74 h and area under curve from zero time to infinity (AUC0-∞) was 20.37 μg/mL/h. The serum concentrations of cefquinome along 24 h post-injection in this study was exceeding the MICs of different susceptible micro-organisms responsible for serious disease problems. These findings indicate the suitability of successful use of this antibiotic in camels. A recommended single daily dose of 1 mg kg-1 of cefquinome given intramuscularly can achieve quite therapeutic concentrations in serum, that exceeding the minimal inhibitory concentrations against different susceptible pathogens.
  A.Y. Al-Taher , M.K. Zabady , A.I. Almubarak , M. Ismail and R.O. Ramadan
  This study was conducted to evaluate the analgesic and sedative efficacy of the combination of tramadol-xylazine used in six dromedary camels underwent soft tissue surgeries and premidicated with Intravenous (IV) 0.2 mg kg-1 of xylazine. The combination was induced IV with 2.0 mg kg-1 of tramadol and 0.2 mg kg-1 of xylazine, IV top-up of the combination of the same original doses was injected whenever the analgesia was inadequate or when surgical stimulation provoked movement. A surgically satisfactory analgesia was achieved and maintained in all camels by this combination except in two camels that underwent perineal laceration and castration showing signs of distress and pain as the injection dose was insufficient even after a supplemental dose at the same original dose was administered. Mean time±SD from administration of the combination of tramadol-xylazine until end of operation was 39.5±10.1 min. This study concludes that the combination of tramadol-xyalzine was effective and safe to use in camels and suggests that combination can be improved upon by combining with local analgesic drug to achieve adequate depth of analgesia.
  A.Y. Al-Taher
  The pharmacokinetics of difloxacin delivered by both Intravenous (IV) and Subcutaneous (SC) routes and its metabolic profile and elimination pattern following the subcutaneous administration of 5 mg kg-1 were investigated in a crossover study using 10 camels (Camelus dromedaries). Multiple plasma, faecal and urine samples were collected for the quantitation of difloxacin and its metabolites using HPLC with fluorescence detection and mass spectrometry for the elucidation of metabolite structure. Difloxacin was eliminated from plasma with elimination half-lives of 6.65 and 7.52 h following Intravenous (IV) and Subcutaneous (SC) administration, respectively. The drug was absorbed slowly following SC administration and a maximum concentration of 2.1 μg mL-1 was attained at (Tmax) 4 h with a bioavailability of 94.6%. Difloxacin was metabolised in camels by the N-demethylation pathway to produce the active metabolite sarafloxacin (M1) and by oxidation into three other metabolites, 3-oxosarafloxacin (M2), 3-oxodifloxacin (M3) and desethylenesarafloxacin (M4). The concentrations of the circulating Metabolites in plasma (M1, M2 and M3) were much lower than that of the parent drug. The administered dose of difloxacin was eliminated largely in its parent form in faeces (69.5%) and to a small extent in urine (5.9%) whereas sarafloxacin (M1) and 3-oxosarafloxacin (M2) were the main metabolites detected in faeces (7.2 and 3%) and urine (3.5 and 1.8%). The other metabolites, 3-oxodifloxacin (M3) and desethylenesarafloxacin (M4) were detected to a minimal extent in faeces only and amounted to 1.47 and 0.6% of the dose, respectively. The results of the present study revealed that the N-demethylation and oxidative pathways of biotransformation are the primary routes of difloxacin metabolism in camels with renal and hepatobiliary excretion through urine and faeces. Phase II conjugation plays a minor role in the elimination of the drug in camels.
  N.H. Mohammed , M.I. Mostafa and A.Y. AL-Taher
  New thymoquinone derivatives bearing thiazolidine moiety (2-6) were designed and synthesized in one pot facile addition reaction. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. The in-vitro antitumor activity of the obtained compounds has been evaluated.
  N.H. Mohammed , Mohamed I. Mostafa and A.Y. AL-Taher
  New naringenin derivatives bearing halogen moiety (1-6) were designed and synthesized. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. The in-vitro antimicrobial activity of the obtained compounds has been evaluated. All new analogues tested show inhibitory activity against microorganisms under investigation, the most potent compounds are 1-4. The rest of compounds show nearly same antimicrobial activity as ciprofloxacin reference drug used in this study. The new analogues showed also augmentation effect when used together with ciprofloxacin.
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