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Articles by A.Y. Abbas
Total Records ( 2 ) for A.Y. Abbas
  R.A. Umar , M.J. Ladan , S.W. Hassan , Y. Sa`id , A.Y. Abbas and I.B. Oduolisaeme
  The sub-Saharan African region is home to the greatest burden of Human Immunodeficiency Virus infection and Acquired Immunodeficiency Syndrome (HIV/AIDS). Appropriate management of infectious diseases is the most cost effective intervention to reduce the burden of disease. Highly Active Anti Retroviral Therapy (HAART) is the mainstay for inhibiting the multiplication of the causative agent and improving quality of life of the victims. There is some doubt in the region regarding the safety of the drugs in the anti AIDS pharmacy. Local studies on the safety of these agents are few. We studied the effects of acute and sub-acute oral administration of Lamivudine, Nevirapine and Stavudine on haematological profiles in albino rats. The rats were administered acute and sub-acute doses of Lamivudine, Nevirapine and Stavudine. Packed Cell Volume (PCV), total white blood cell count and differentials were determined by standard haematological methods. There were no significant differences (p<0.05) in the parametres except in PCV, eosinophils, neutrophils and leucocyte count associated with nevirapine and leucocytes and eosinophils associated with lamivudine. We conclude that acute and sub-acute oral administration of these drugs is associated with few haematological abnormalities and is therefore safe.
  S.W. Hassan , R.A. Umar , I.K. Matazu , H.M. Maishanu , A.Y. Abbas and A.A. Sani
  The effect of sun, oven and solar drying on the nutrients and non-nutrients composition of leaves of Leptadenia hastata was investigated. All the drying methods were found to significantly decrease (p<0.05) magnesium content in sun (1.49±0.49 mg 100 g-1), followed by oven (1.27±0.06 mg 100 g-1) and the lowest in solar dried (0.93±0.07 mg 100 g-1) leaves compared to fresh sample. Drying methods with exception of oven drying did not significantly (p>0.05) lower lipids content. The drying processes employed significantly (p<0.05) decreased carbohydrate, crude protein, magnesium and moisture content. Potassium, ash and crude fibre were significantly (p<0.05) increased. Oven drying significantly reduced acid value (2.82±0.41%), followed by sun (2.12±0.65%) and solar drying (1.76±0.21%) in decreasing order. Tannins, saponins, volatile oils, saponin glycosides and alkaloids were detected in fresh and dried samples. These compounds with exception of saponins and saponin glycosides (sun and oven dried) decreased in trace amounts upon drying. The results reinforce the growing awareness that the leaves of Leptadenia hastata can contribute useful amounts of nutrients to human diets and reduction of toxic non-nutrients compounds upon drying.
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