Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by A.W. Tekeleselassie
Total Records ( 1 ) for A.W. Tekeleselassie
  A.W. Tekeleselassie , M.A. Rajion , Y.M. Goh , M. Moteshakeri , A.F Soleimani and M. Ebrahimi
  Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 and n-6 Polyunsaturated Fatty Acids (PUFA). The current study was designed to assess the influence of High Fat Diet (HFD) with different n-6: n-3 Fatty Acid Ratios (FAR) on insulin sensitivity, plasma triacylglycerol (TAG) and lipoprotein profile. Forty male Sprague-Dawley rats were randomly allocated into four groups and received the isocaloric high fat diets enriched with either high n-6: n-3 fatty acid ratio (HFAR), medium n-6: n-3 fatty acid ratio (MFAR), low n-6: n-3 fatty acid ratio (LFAR) and compared with control rats fed standard chow (CTRL). The plasma insulin level of HFAR fed rats manifested significantly (P<0.05) higher concentration in most of the time points compared to the other groups. The corresponding insulin AUC (ng/L/120min) and insulin sensitivity index of HFAR fed rats appeared to be significantly higher (P<0.05) than CTRL (335.5±38.5), LFAR (273.7±37.6) and MFAR (265.9±21.7) groups. Blood lipid profile were found to be healthier in the LFAR and MFAR supplemented groups with significantly (P<0.05) lower total cholesterol and TAG levels. This study showed the possible protective effect against insulin resistance when low n-6: n-3 fatty acid ratio in high fat diets are applied in a rat model.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility