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Articles by A.U. Ekanem
Total Records ( 3 ) for A.U. Ekanem
  Paul A. Nwafor , T.W. Jacks and A.U. Ekanem
  The effect of methanolic extract of Pausinystalia macroceras stem-bark was investigated in chemically-induced inflammation in rodents. The extract dose-dependently (17.5-350.0 mg kg-1) inhibited acetic acid-induced writhing, formalin-induced pain licking and carrageenin-induced hind paw oedema in rodents. The extract also inhibited both the fresh egg albumin and prostaglandin E2_induced inflammations as well as capsaicin-induced nociception in rats. These inhibitions were statistically significant (p<0.01-0.001). This effect may in part involve suppression of capillary permeability through neurogenic and non-neurogenic pathways.
  A.U. Ekanem , S.H. Garba , T.S. Musa and N.D. Dare
  The ear is an important and under-recognized defining feature of the face whose shape conveys information about age and sex that is clearly difficult to characterize. This study was designed to generate anthropometric, normative cross-sectional data on the adult ear auricle in Nigerians. It was also aimed at showing the morphological and aesthetic differences between males and females; as well as changes in ear morphology with age. A total of 217 adult Nigerians (aged 18-65 years) who met the inclusion criteria were enrolled into the study. Standardized measurements of the ear pinna (total ear height, lobular height and lobular width) were undertaken. The data were analyzed using SPSS version 10.0. The mean total ear height and mean lobular height across the cohort were 5.60 and 1.11 cm, respectively, while the average lobular width measured 1.35 cm. The results indicates that the mean total ear height and mean lobular height were higher in the males than in the females while the females had a higher mean lobular width of 1.37 cm than the mean lobular width of 1.33 cm in males. There were increases in earlobe height and lobular height but a decrease in lobular width with advancing age. This study has shown that age related changes in ear morphology do exist in Nigerians and the changes were with respect to sex from adolescence to the age groups of 41-45 years. But further study to relate the results of our present study to the height of individual and some facial/cranial anthropometric parameters is going on.
  A.U. Ekanem , S.H. Garba and A.G. Jankada
  The effect of Aspirin (ASA) and indomethacin (Indocin) on the histomorphology of the female reproductive organs was investigated. A total of 60 female albino rats of the Wister Strain were randomly divided into 12 groups of 5 rats each (group’s 1-12). Groups 1 and 2 served as the control groups and were administered normal saline and dimethylsulfoxide (DMSO 5 mg kg-1 body weight), respectively for 14 days. Groups 3-7 were administered 10, 25, 50, 75 and 100 mg kg-1 body weight of aspirin respectively for 14 days while groups 8-12 received 2.0, 2.5, 3.0, 3.5 and 4.0 mg kg-1 body weight of indomethacin respectively for 14 days. At the end of the 14 day, the animals were sacrificed and the ovary, uterine tubes and uterus obtained for routine histological processing and subsequent histopathological assessment. Results from this study showed normal histological profiles of all organs obtained from the rats in the control groups while the experimental groups treated with aspirin and indomethacin presented with vasoconstriction in the ovary and atrophy of smooth muscles of the uterine tubes and uterus. This study has establish to some extent, the vasoconstrictive potency of aspirin and indomethacin and thus providing an experimental basis for the use of these drugs to reduce and if possible stop ovarian and uterine hemorrhage but further investigation to elucidate the vasoconstrictory effect, smooth muscle atrophy and the reversibility of some of the toxic effect of these drugs on the female reproductive organs and the mechanism involved is recommended in further studies.
 
 
 
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