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Articles by A.T.M. Zafrul Azam
Total Records ( 2 ) for A.T.M. Zafrul Azam
  Md. Harun-Or-Rashid , Nurul Karim , M.A. Gafur , Md. Golam Sadik , A.S.M. Anisuzzaman , Noaki Sugimoto and A.T.M. Zafrul Azam
  Extensive chromatographic separation and purification of the organic solvent extracts of stem of I. turpethum afforded three compounds, N-p-coumaryl tyramine (EH4), daucosterol (CH1) and 2-hydroxybenzoic acid (CH2); first isolated from this plant. The structures of these compounds were determined by spectroscopic analysis, including 1H- and 13C-NMR, as well as by UV, IR and electrospray ionization mass spectrometry (ESI-MS). On screening against pathogenic bacteria and fungi; compounds CH2 and EH4 as well as extracts showed significant antibacterial and antifungal activity. The Minimum Inhibitory Concentration (MIC) against Bacillus subtilis and Shigella dysenteriae of compounds CH2 and EH4 were 64 μg mL-1. On in vivo cytotoxicity studies against brine shrimp; compounds CH2 and EH4 showed LC50 (Leathal concentration for 50% mortality) values 54.03 and 43.41 μg mL-1, respectively.
  A.H.M. Rashidul Bari , A.T.M. Zafrul Azam , Md. Shah Amran and Md. Amjad Hossain
  An in vivo study has been carried out to evaluate the influence interaction of ibuprofen and naproxen on the plasma concentration of diltiazem in rabbits. The study has bee carried out by UV Spectrophotometric method. It has been found that the concurrent administration of diltiazem and ibuprofen has no effect on plasma concentration of diltiazem in rabbits. But concurrent administration of diltiazem and naproxen causes a significant decrease in plasma concentration of diltiazem. These results indicate that great care and monitoring is to be practiced during concurrent administration of diltiazem with naproxen to avoid untoward pharmacological and therapeutic actions related to drug-drug interactions.
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