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| Articles
by
A.S.M. Anisuzzaman |
Total Records (
2 ) for
A.S.M. Anisuzzaman |
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A.S.M. Anisuzzaman
,
Naoki Sugimoto
,
Golam Sadik
and
M.A. Gafur
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The sub-acute toxicity studies of 5-Hydroxy-2 (Hydroxy-methyl) 4H- pyran-4 one, a metabolite of Aspergillus fumigatus was carried out in rats. The compound was administered at a dose of 300 μg/rat/day for 21 days. The gross general observation such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of the liver, kidney, heart, lung, spleen were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The change of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. |
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Md. Harun-Or-Rashid
,
Nurul Karim
,
M.A. Gafur
,
Md. Golam Sadik
,
A.S.M. Anisuzzaman
,
Noaki Sugimoto
and
A.T.M. Zafrul Azam
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Extensive chromatographic separation and purification of the organic solvent extracts of stem of I. turpethum afforded three compounds, N-p-coumaryl tyramine (EH4), daucosterol (CH1) and 2-hydroxybenzoic acid (CH2); first isolated from this plant. The structures of these compounds were determined by spectroscopic analysis, including 1H- and 13C-NMR, as well as by UV, IR and electrospray ionization mass spectrometry (ESI-MS). On screening against pathogenic bacteria and fungi; compounds CH2 and EH4 as well as extracts showed significant antibacterial and antifungal activity. The Minimum Inhibitory Concentration (MIC) against Bacillus subtilis and Shigella dysenteriae of compounds CH2 and EH4 were 64 μg mL-1. On in vivo cytotoxicity studies against brine shrimp; compounds CH2 and EH4 showed LC50 (Leathal concentration for 50% mortality) values 54.03 and 43.41 μg mL-1, respectively. |
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