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Articles by A.R. Mansourian
Total Records ( 9 ) for A.R. Mansourian
  S. Bakhshande- Nosrat , E.A. Ghaemi , A. Ahmadi , N. Behnampour , A. Marjani and A.R. Mansourian
  Copper is an integrated parts of metal-protein required far varieties of oxide-reductive metabolic pathways in human. Copper deficiency is considered as risk factors in some pregnancies. Premature rupture of membrane is a pregnancy complication with major adverse effects and is believed maternal Copper deficiency can also be considered as interventional factors. This study was done to evaluate if there is a correlation between maternal serum Copper concentration and premature rupture of membrane in pregnancy. In this case-control study 60 pregnant women with Premature Rupture of Membrane (PROM) were selected as case group including term and pre term the control group consist of 60 pregnant women with normal delivery of term and pre term states. Both group were matched for maternal and pregnancy age. In case and control group the pregnancy at term and pre-term were grouped independently as well. In general the maternal mean serum Copper concentration were 192.4±78.2 and 201.08±82.06 in case and control groups, respectively but this differences statistically was not significant. Data in this study revealed that the absolute value of maternal serum Copper concentration of term or pre term in case groups was slightly lower than related controls. Drop in maternal Copper concentration in some disturbed pregnancies such as premature rupture of membrane is previously demonstrated and based on our data the absolute Copper serum concentration of women with premature rupture of membrane was also slightly lower compared to healthy pregnancy but it was not statistically significant.
  F. Shahmohammdi , A.R. Mansourian and H.R. Mansourian
  The aim of this study was to establish the relationship between the serum Thyroid Stimulating Hormone (TSH) and thyroxin (T4) which reflect thyroid function assessment, with nausea and vomiting, among pregnant women in early pregnancy. In present study 60 pregnant women without nausea and vomiting compared with 60 pregnant women with nausea and vomiting during 2007-2008. Two groups of case and control were matched. Patients with nausea and vomiting did not have significant differences when compared with control subjects in TSH level, the data from this investigation indicated that, T4 level elevated among 34 subjects (56.6%) with nausea and vomiting compared to 20 subjects (33.3%) of women without nausea and vomiting. These data suggest that there is a role for elevated T4 in nausea and vomiting among pregnant women, in early pregnancy.
  G.R. Veghari , A.R. Mansourian and A.J. Marjani
  The main purpose of this study is the comparison due to Iron deficiency in the villages of Gorgan city. Forty eight and 361 non-pregnant women were be classified in two groups for comparing among 415 women of 18-35 years old were chosen by compound sampling. After sampling, hematological examination was done by using Coulter counter in 9000 model and measuring of the serum iron and Total Iron Binding Capacity (TIBC) were performed by using spectrophotometery. In the pregnant women, serum Iron less than 30 mic g dL-1, Hemoglobin less than 11 g dL-1, Transferrin Saturation (TS) less than 16% were be consider as anemia point and in non-pregnant women, this point is the serum iron less than 40 mic g dL-1, hemoglobin less than 12 g dL-1 and TS less than 16%. In pregnant women, the prevalence of the anemia on the basis of serum iron index, TS and Hb in seen 24.2, 42.4, 18.2%, respectively and in non-pregnant women is 21.2, 34.55 and 20.98%. In pregnant and non-pregnant women, the Mean Corpuscular Volume (MCV) is 83.48 and 85.34 Flit. There is a significant statistical differences on base of mean of Mean Corpuscular Hemoglobin (MCH) and MCV among non-pregnant and pregnant women in 1st, 2nd and 3rd trimester (p<0.005). On the time of the sampling, 33% of pregnant and 8.4% of non-pregnant women have used Iron compounds. The results of this study shows in pregnancy period, supplement of the iron is necessary and person`s need must be evaluated before prescribing drug.
  A.R. Mansourian , A. Saifi , M.A. Vakili , A. Marjani , E. Ghaemi , A. Moradi and A.R. Ahmadi
  This study was carried out to evaluate the pattern of antibiotics prescribed by either General Physician or specialist, mostly practiced medicine in the private sectors, in Gorgan, Located in south-east Caspian sea in the northern Iran. This research was a prospective study, using a pharmacist administrated questionnaires to record the prescribed antibiotics. The findings indicated amoxicillin, cephalexin, penicillin, with 31.4, 21 and 17.4% are among the most widely prescribed antibiotics, respectively. ENT specialist prescribed the highest rate of antibiotics (24.1%), although as whole General physicians are among high antibiotics prescribing doctors, with such rate of antibiotics prescription, an educational program, among the community health centers, especially for young physicians on the need for antibiotics therapy and risk factors associated with increase rate of antibiotic resistant organism are suggested.
  G.R. Veghari , A.R. Mansourian and A.J. Marjani
  Anemia is one of the nutritional difficulties in third world (developing countries). Various factors including ecological play a role in causing anemia. This study was set up to determine iron deficiency anemia and anemia due to iron deficiency among the groups of women (Fars-native, Turkaman and Immigrant Sistanee) in villages around Gorgan. According to earlier studies it was decided to study on 415 women age 18-35 year (Fars-native = 128, Turkaman = 128 and Sistanee = 103). The sample population was chosen from 20 villages using random-clustering method. Hematological indexes and biochemical tests (serum iron and TIBC) were determined. In this study the Transferrine saturation rate <16% and Hb concentration <12 g dL-1 was considered as iron deficiency and anemia respectively. The combination of iron deficiency and anemia was considered to be as iron deficiency anemia taking notice of reference value for the pregnant woman. The prevalence of iron deficiency in Fars- native, Turkaman and Sistanee women 33.6, 47.6 and 26.2%, respectively. The rate of anemia on the same women 27.7, 18.75 and 22.33% and iron deficiency anemia were 15.6, 11.9 and 11.3%, respectively. χ2-Test showed a meaningful in regard to iron deficiency and anemia among the three groups of women (p<0.005) was seen. A significant statistical correlation was seen between Hb and MCHC in Fars- native (r = 0.457, p<0.001), Turkaman (r = 0.294, p<0.01) and Sistanee women (r = 0.467, p<0.001). This correlation is strong enough in Turkaman race. From the results of this study it can be concluded that in addition to prevalence of anemia its characteristic also is different among the three groups of women. It should be added that anemia is one of the women nutritional problems in the village around Gorgan.
  A.R. Mansourian , E.O. Ghaemi , A.R. Ahmadi , A. Marjani , A. Moradi and A. Saifi
  The purpose of this study was to describe the distribution of serum prostate specific antigen (PSA) and to determine age-specific reference range in a population of Persian men. Venous blood samples were taken from 287 men, from Gorgan located in the North of Iran, South-East of Caspian Sea, aged 15≥80 year. The serum PSA levels was measured using Enzyme-linked Immunosorbant-Assay (ELISA) technique and age-specific range for PSA level was determined. The serum prostate-specific antigen level for six age group of 15-40 years, 41-50 years, 51-60 years, 61-70 years, 71-80 years and >80 years were mainly in the range of 0-2.5 ng mL-1, for 76.6%, 2.6-4 ng mL-1 for 9.1% and as whole 85.7% of all men in this study had ≤4 ng mL-1, 8.7 and 5.6% all men of six age group had PSA level of 4.1-10 ng mL-1 and >10 ng mL-1, respectively. The findings of present study indicated that a large proportion (76.6%) men in this region have a lower PSA level of 0-2.5 ng mL-1 and only 9.1% of men have PSA level of 2.6-4 ng mL-1. It is therefore concluded that acceptable reference range of 0-4 ng mL-1 for PSA level require further reassessment.
  A.R. Mansourian
  Hypothyroidism, is a thyroid disorder accompanied by serum thyroid hormone reduction when thyroxin T4, the main thyroid hormone, reduced, it is followed by disruption of a negative-feed back auto regulatory mechanism on pituitary gland and subsequent thyroid stimulating hormone (TSH) which is released into the blood circulation to stimulate the thyroid gland to produce enough thyroid hormone to compensate for the body hormone requirements. Therefore, reduced serum thyroxin(T4) in principle, triidothyronine (T3) and elevated TSH are laboratory indices for the diagnosis of hypothyroidism. At early stage of hypothyroidism although laboratory measurements of thyroid function test are manifest the thyroid disorder but the patient clinical signs and symptoms may remain unnoticed. If the patient undiagnosed and untreated the condition of hypothyroidism worsen and the clinical manifestation begin to show itself and myxedema is a definition given to the whole picture of untreated hypothyroidism at very end stage the patients enter into myxedema comma with eventual death due to the sever symptoms of hypothyroidism. Among important causative factors leading to catastrophic events in myxedema is life threatening hypothermia, heart and cerebral dysfunctions.
  A.R. Mansourian , A.R. Ahmadi , A. Saifi and S. Bakhshandehnosrat
  Hypothyroidism is associated with mental and growth abnormality in children. The aim of this study was to determine the reference range of thyroid stimulating hormone (TSH). Thyroxin (T4) and triodothyronine (T3) of children in Northern Iran. The sample population for this study consists of subjects of 4 age groups up to 21 years. The subjects were selected randomly from people referred to Danesh Medical Diagnostic Laboratory in Gorgan Northern Iran. Thyroid hormone level were investigated with Radio immunoassay. The mean concentration for T4, T3, TSH for the sample population of 4 groups were as follow (113.5, 107.4, 102.9, 99.2 nmol L-1), (1.9, 1.7, 1.9, 1.6 nmol L-1) and (2.1, 3.5, 2.9, 2.7 mIu L-1). The mean value of T3, TSH were higher for females but the mean value of T4 was slightly higher in males. The findings of this investigation indicated that there is an inverse age correlation in particular for T4 in all age groups. On the bases of the results from this study, we conclude that reference range, in all age groups and lower, upper limits of our reference range are not universally similar; therefore determination of reference range in each region is a critical need for clinical practice.
  A.R. Mansourian
  Tetraidothyronine (T4) and Triiodothyronine (T3) are the two vital hormones in human metabolism produced by thyroid gland. The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg. Oxidized iodine and tyrosyle residues which are an aromatic amino acids are integral part of T4 and T3. The thyroid iodine deficiency of either dietary, thyroid malfunction , or disorder of hypothalamus and pituitary to produce enough Thyroid Stimulating Hormone (TSH), eventually lead to hypothyroidism with sever side effects. Iodine oxidation is the initial step for thyroid hormone synthesis within thyroid, is mediated by thyroperoxidase enzyme (TPO), which itself is activated by TSH required for production of MIT and DIT. T4 and T3 are subsequently are synthesized on Tg following MIT and DIT coupling reaction. Thyroid hormones eventually produced and released into circulation through Tg pinocytosis from follicular space and subsequent lysozomal function, a process again stimulated by TSH. The production of T4 and T3 are highly regulated externally by a negative feed-back interrelation between serum T4, T3 and TSH and internally by the elevated iodine within thyroid gland. It is believed the extra iodine concentration within thyroid gland control thyroid hormones synthesis by inhibition of the TPO and hydrogen peroxide (H2O2) formation which is also an essential factor of iodine oxidation, via a complex mechanism. In healthy subjects the entire procedures of T4 and T3 synthesis re-start again following a drop in serum T4 and T3 concentration. On conditions of thyroid disorders, which caused by the distruption of either of above mechanisms, thyroid hormone deficiency and related clinical manifestations eventually begin to show themselves.
 
 
 
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