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Articles by A.P. Igbakin
Total Records ( 2 ) for A.P. Igbakin
  S.A. Laleye , A.P. Igbakin and J.A. Akinyanju
  The effect of Nono (a Nigerian fermented milk) on diabetic situation in rats, induced by intraperitonial injection of alloxan monohydrate is reported. Nono administration for 4 weeks lowered the raised plasma glucose concentration of diabetic rats; restoring it to the non diabetic rat level. The low tissue protein and raised plasma protein concentrations; hyperlipidemia; and hypercholesterolemia consequential on diabetic induction were reversed to the normal level by the Nono administration. The reversals of these effects of diabetes may be due to the lowering of the plasma glucose concentration by Nono or direct activity of either the bacteria or milk components of Nono on these substances. The results indicate that consumption of Nono produced by wild strain lactic acid bacteria may be helpful in the management of diabetes.
  A.P. Igbakin and I.G. Adanlawo
  The effect of solvent extracts (ethanol and normal saline) of the seed of Parimari microphylla was investigated on alloxan induced diabetic rats. Rats were administered orally with 500 mg kg-1 body weight of the extracts over a period of five weeks. Plasma glucose, total lipids and cholesterol levels of the animals were monitored throughout the period of the experiment. Also determined were the tissue cholesterol, total lipids, pyruvate and glycogen. The results shows high level of plasma glucose, total lipids and cholesterol i.e., hyperglycemia, hypperlipidemia and hypercholesterolemia, respectively in all the diabetic treated rats except those administered with the ethanolic extract of P. microphylla (EEPM) which reduced the plasma glucose, total lipids and cholesterol of the diabetic animals significantly (p<0.05). Also the elevated tissue pyruvate, total lipids and cholesterol in the diabetic rats were equally reduced significantly (p<0.05) by EEPM and their reduction is favourably compared to that of the control. EEPM increased the reduced tissue glycogen significantly (p<0.05). These results show that the EEPM possesses antidiabetic properties which can normalise all the alterations associated with metabolites in diabetic animals.
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