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Articles by A.O. Oyewale
Total Records ( 3 ) for A.O. Oyewale
  A.B. Aliyu , M.A. Ibrahim , A.M. Musa , T. Bulus and A.O. Oyewale
  Leaf extract and fractions of Vernonia blumeoides were evaluated for total phenolics content (Folin-Ciocalteu method), free radical scavenging activity (1, 1-diphenyl-2-picrylhydrazyl radical assay), total antioxidant capacity (Phosphomolybdate assay) and ferric reducing power. The results of the phenolics content expressed in mg/100 g of Gallic Acid Equivalent (GAE) showed that the n-butanol fraction has significantly (p<0.05) higher phenolics content (410±0.8) than the chloroform fraction and ethanol extract. The radical scavenging activity of the extract and solvent fractions displayed strong concentration dependent activity. But it was also observed that the ethyl acetate fraction showed highest activity in all concentration tested ranging from 70.56 to 99.04%. However, the total antioxidant capacity (mg g-1 ascorbic acid) showed that n-butanol fraction has the highest capacity (60.0 mg g-1). The results also showed that the n-butanol extract has strongest reducing ability (2.105±0.109 nm) at higher concentration which is comparable to that of Gallic acid at all the concentrations tested. Phytochemical screening on the extracts revealed the presence of flavonoids, saponins and tannins. The results suggest that the plant especially the n-butanol and ethyl acetate fractions are very rich in antioxidant compounds worthy of further investigations.
  R.G. Ayo , J.O. Amupitan and A.O. Oyewale
  The aim of the study was to scientifically validate the claims that C. nigricans is used in traditional medicine for the treatment of skin diseases, infections and wounds. The leaves of Cassia nigricans is said to be used in traditional medicine for the treatment of peptic ulcer, gastro-intestinal disorders, diarrhoea and skin diseases. The glycoside present in the methanol extract of the leaves was hydrolysed using dilute hydrochloric acid. A silica gel column of the resulting aglycone (using petroleum ether:ethyl acetate mixtures) gave a white amorphous powder, identified as steroidal ester by means of spectral analysis. The antimicrobial activity of the steroidal ester was investigated against Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium pyogenes, Bacillus subtilis, Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Neisseria gonorrhoeae and Klebsiella pneumoniae using agar diffusion technique. The results showed that the compound was effective against all the test organisms and the minimum inhibitory concentration was found to be 2x103 μg mL-1.
  A.B. Aliyu , A.M. Musa , M.S. Sallau and A.O. Oyewale
  Biochemical studies with a view to assess the nutritional potentials of Anisopus mannii were carried out by evaluating the proximate composition, mineral elements and anti-nutritional content of the plant. The results showed that the total oxalates, free cyanides, tannins and total cyanides were found to be present at 0.70 ± 0.5, 6.50 ± 0.41, 10.55 ± 0.01 and 12.41 ± 7.19%, respectively. However, concentration of phytate was very low (0.017 ± 0.00%). Proximate compositions of the plant showed a rich source of crude protein (8.40 ± 0.17%), fats (8.67 ± 0.63%), carbohydrates (72.57 ± 0.68%) and total ash (10.36 ± 0.22%). The plant was also found to contain the following essential minerals: potassium (1700 mg/100 g), calcium (1280 mg/100 g), iron (156 mg/100 g), vanadium (102 mg/100 g), chromium (53.90 mg/100 g), zinc (0.874 mg/100 g), copper (1.43 mg/100 g) and manganese (36.60 mg/100 g). The results of this research indicated that Anisopus mannii has nutritional qualities that could provide the users with additional nutrients for enhanced curative process of ill health.
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