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Articles by A.O. Oluduro
Total Records ( 2 ) for A.O. Oluduro
  A.O. Oluduro and B.I. Aderiye
  The efficacy of Moringa oleifera seed (LAM) in reducing total bacteria and coliforms in raw water was studied. Its antibacterial activity on some selected enteric bacterial pathogens was also investigated. About 88 and 97.5% of the total bacteria and coliforms,, respectively were reduced in the surface water after 24 h of treatment. Meanwhile, in the underground water sample, the seed extract reduced the total bacteria and coliforms by 88.3 and 93.3% with a precipitation rate of 7.7H102 and 2.42H102 cfu hG1, respectively. The coagulating efficiency and zones of inhibition increased correspondingly with an increase in concentration of the seed extract. At a concentration of 30μg mLG1, there was no microbial growth recorded in the water samples even after 96 h storage. However when Escherichia coli, Salmonella typhi and Shigella dysenteriae were exposed to the seed extract, a secondary bacterial growth resulting into an increase of about 185, 189 and 198% in their concentrations, respectively was observed after 24 h. The minimum inhibitory concentration of the seed extract ranged between 20 and 50μg mLG1.
  O.M. David , A.O. Oluduro , Shitttu , O.A. Olowe and O. Famurewa
  Haematological, enzymatic and histopathologic changes during gelatinase positive (gel+) Enterococcus feacalis infection was assessed in an animal (albino rat) model using standard methods. The role of gelatinase in post-enterococcaemia was established. White Blood Cell (WBC) count, Packed Cell Volume (PCV) and platelets were significantly reduced (at p≥0.05) in gelatinase positive (gel+) than in gelatinase-negagive (gel¯) compared to the controls. The enzymes Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Acid Phosphatase (ACP) and Alkaline Phosphatase (ALP) showed the following values 105, 43, 39.39 and 102.63 IU L-1, respectively for the gel+ infected animas, 108, 57, 164.6 and 428.94 IU L-1, respectively for gel¯ and 108, 67, 77.77 and 202.63 IU L-1, respectively for the control. The results obtained for the bilirubin test were 18.5 mg dL-1, total bilirubin and 7.83 mg dL-1 conjugated bilirubin for gel+ infected animas, total and conjugated bilirubin recorded 7.4 and 2.46 mg dL-1, respectively in gel¯ infected animas and 5.55 and 4.92 mg dL-1, respectively in the control. Histopathological changes within the individual groups varied and overall changes were less extensive than observed in animals infected with gel+ E. faecalis. Thin section showed an overall loss of structural integrity. The results show areas of pronounced haemorrhage, necrosis with bacterial clusters and distortion in morphology. There was a striking difference in the severity of lesions between gel¯ and gel+ infected animal. However, in an intraperitoneal rat infection model, gel+ strain was relatively less pathogenic. These findings highlight the importance of gelatinase as a pathogenic factor and are likely key determinants important to pathogenesis of pathogens.
 
 
 
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