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Articles by A.O. Ojiako
Total Records ( 2 ) for A.O. Ojiako
  C.S. Alisi , A.O. Ojiako , G.O.C. Onyeze and G.C. Osuagwu
  The major functions of the liver can be detrimentally altered by liver injury resulting from acute or chronic exposure to toxicants. Dyslipidemia is often found in such toxicity resulting from chemical damage. Normalisation of atherogenic indices by Chromolaena odorata (C. odorata ) in carbon tetrachloride-induced liver toxicity was evaluated in 30 male rabbits divided into 5 groups of 6 animals each. Normal Control (NC) received food and water only. Carbon tetrachloride intoxicated control (CCl4) received a single dose of CCl4 (0.2 mL kgbw-1 in liquid paraffin 1:1). C. odorata test animals (ETECO TEST) received a single dose of CCl4 + ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1 morning and night, for 6 days. C. odorata control animals (ETECO CTRL) received ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1. Group five (Sylimarin) received sylimarin 50 mg/kgbw prior to CCl4 intoxication. Carbon tetrachloride-induced toxicity resulted in liver injury which was seen from the significant (p<0.05) elevation of the activities of serum Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Lactate Dehydrogenase (LDH) and gamma-Glutamyl Transferase (γ-GT), significantly decreased protein and albumin and significantly increased total bilirubin concentrations; altered lipid and lipoprotein phenotypes in favour of increased atherogenic indices. Pre-treatment with C. odorata extract prevented these biochemical alterations and normalized the lipoprotein phenotypes. C. odorata may be useful not only as a hepatoprotective agent, but also in the reduction and/or prevention of adverse cardiovascular events.
  C.U. Igwe , A.O. Ojiako , J.E. Okwara , A.A. Emejulu and R.N. Nwaoguikpe
  Twenty-four male albino rats, 4 weeks old were randomly distributed into 4 groups (A-D) and fed growers’ mash as the control diet and 25, 50 and 75% oven-dried, ground Macrotermes nigeriensis fortified diets respectively for a total period of 28 days. The effects of the diets on hepatic, renal and haematologic function indices of albino rats were studied. The animals fed the fortified diets had non-significantly (p>0.05) lesser body weight gains than the control animals. The fortified diets elicited dose-dependent increases in the levels of blood total protein, albumin, packed cell volume, hemoglobin and red blood cell counts as well as on the calculated red cell indices. The fortified diets did not significantly (p>0.05) alter the activities of plasma alanine and aspartate aminotransferases as well as the concentrations of total bilirubin, urea and creatinine. The results indicate that the fortified diets do not have detrimental hepatic, renal or haematologic effects but rather may be recommended for fortification of human and animal food, especially in weaning diets of growing children and nursing mothers to combat food insecurity and malnutrition.
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