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Articles by A.O. Soladoye
Total Records ( 2 ) for A.O. Soladoye
  L.A. Olayaki , M.S. Ajao , J. Ayo , M.T. Ayinla and A.O. Soladoye
  Women during menstrual cycle have demonstrated variability in cardiovascular responses, including flow mediated dilatation and calcium levels in cervical secretions. The experiment was designed to study the relationship between plasma calcium ions and some cardiovascular changes during the phases of menstrual cycle. Twenty young women aged 19-24 years with menstrual cycles that were regular and 27-30 days in length participated in the study. Venous blood sample was collected for plasma Ca2+ estimate using colometric method and callidy blue reagent and glycoetherdiamine as diluting agent. Systolic Blood Pressure (SBP) increased from 113.40±4.73 mmHg to 118.53±3.42 during the early follicular to the periovulatory phase. The difference is statistically significant (p< 0.05). There was no statistical difference in the level of Diastolic Blood Pressure (DBP) measured across the menstrual cycle. The Heart Rate (HR) increased from 74.40±5.03mmHg during the early follicular phase to 86.73±8.24 mmHg during the periovulatory phase and then reduced to 90.73±8.96 mmHg during the mid-luteal phase. Both the increase and subsequent decrease were statistically significant (p< 0.05). Plasma Ca2+ concentration peaked at periovulatory phase i.e. concentration of 9.85±0.41 mg dL 1 compare to 8.65±0.61 mg dL 1 during the early follicular phase (p< 0.005). and then fell to 9.25±0.75 mg dL 1 during the mid-luteal phase (p< 0.05). The result shows a positive relationship between systolic blood pressure and plasma Ca2+ in pre-menopausal women across the menstrual cycle with both of them peaking at periovulatory phase.
  L.A. Olatunji , A.O. Soladoye , A.A. Fawole , R.O. Jimoh and V.A. Olatunji
  Abnormal haemorheology has been shown to be in almost all conditions associated with accelerated atherosclerotic cardiovascular disorders. The aim of this study is to test the hypothesis that high concentration of plasma Triglyceride (TG) predicts altered hemorheological variables in normal pregnancy. Sixty pregnant women attending antenatal clinic of the University of Ilorin Teaching Hospital at 14-36 weeks of gestation (aged 21-36 years) were recruited after giving informed consent to participate in the study. They consisted of 28 primigravidae and 32 multigravidae. Twenty-four healthy non-pregnant women of similar age and socioeconomical status were also recruited. The study showed that fasting plasma Triglyceride (TG) increased significantly in primigravidae and multigravidae. There was a positive correlation between plasma TG level and blood viscosity (r = 0.36, p<0.01). TG also correlated positively with haematocrit (r = 0.48, p<0.001), haemoglobin concentration (r = 0.43, p<0.001) and white blood cell count (r = 0.38, p<0.01) in the pregnant group as a whole. In primigravidae, there was a correlation between TG and blood viscosity (r = 0.63, p<0.001), hematocrit (r = 0.88, p<0.001), haemoglobin concentration (r = 0.85, p<0.001), white blood cell count (r = 0.40, p<0.05) and total serum protein (r = 0.37, p<0.05). However, there was an insignificant correlation between TG and the haemorheological variables in multigravidae. The study suggests that plasma TG concentration in primigravidae is strongly associated with blood viscosity and its main determinant, haematocrit as well as white blood cell count and haemoglobin concentration, but the association is lost in multigravidae. Therefore, TG could be considered as an important potential indicator of altered blood rheology in primigravidae, but not in multigravidae.
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