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Articles by A.M. Mohamed
Total Records ( 3 ) for A.M. Mohamed
  Z.A. Zakaria , A.M. Mat Jais , M. Mastura , S.H. Mat Jusoh , A.M. Mohamed , N.S. Mohd. Jamil , M.S. Rofiee and M.R. Sulaiman
  The present study was carried out to evaluate the antibacterial activity of the aqueous, methanol and chloroform extracts of several plants available in Malaysia, namely Muntingia calabura (L.), Melastoma malabathricum (L.), Bauhinia purpurea (L.), Corchorus capsularis (L.) and Dicranopteris linearis (L.) using the single screening in vitro microtiter plate dilution methods. The extracts, at the dose of 5 μg μL-1, were screened against various strains of Staphylococcus aureus, namely S. aureus 29213α, S. aureus 33591, S. aureus 700699, vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Results: Interestingly, only the methanol extracts of D. linearis exhibited an antibacterial activity against all strains of S. aureus whereas all extracts of M. calabura were effective only against the S. aureus 29213α, S. aureus 33591 and S. aureus 700699. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for D. linearis range between 0.625-1.250 and 1.250-2.500 μg μL-1, respectively whereas for the M. calabura extracts the MIC and MBC range between 1.250-5.000 and 2.500-5.000 μg μL-1, respectively. Although the other plants gave negative results in this study, their potential antibacterial properties should not be disregarded as the present study was carried out using only one low concentration (5 μg μL-1) and that the activity was determined using crude, but not pure, extracts. The present study demonstrated the potential of chloroform extract of D. linearis, which indicate the present of non-polar bioactive compounds, as VRSA antibacterial agents and all extracts of M. calabura as a potential source of antibacterial agents for the treatment of normal S. aureus infection.
  A.M. Mohamed and Laila M. Faddah
  The objective of present study is to estimate whether the treatment with Viagra in compared to the antioxidative nonenzymatic antioxidant, vitamin E and their synergistic combination would reverse brain disorders of diabetic rats. Animals were divided into two classes, class 1 consists of four normal healthy groups, control (not received any medication) and Viagra, vitamin E and synergistic (Viagra and vitamin E)-treated groups (Gs1, 2, 3 and 4, respectively). Class 2 consists of four diabetic groups injected intraperitoneally with a single dose of alloxane (150 mg kg-1 body weight), diabetic control and diabetic-Viagra, vitamin E and synergistic treated Groups (Gs 5, 6, 7 and 8, respectively). The result revealed that diabetes causes an imbalance in the oxidative state of brain tissue which is confirmed by significant increase in Xanthine Oxidase activity (XO, an enzymes implicated in the production of reactive oxygen and nitrogen species, ROS, RNS, respectively) as well as in nitric oxide (NO, marker of vascular disorder) and malonaldehyde (MDA, index of polyunsaturated fatty acid oxidation) levels with concomitant decrease in the antioxidants, vitamin C and glutathione (GSH) contents. The present investigation also showed that diabetes induces impairment of Adenosine TriphosPhate (ATP) hydrolyzing enzymes, indicated by marked reduction in Na + /K + ATPase activity ,an enzyme responsible for maintaining the ionic gradient necessary for neuronal excitability and stimulation of ectonucleotidases, NTPDases and 5`-nucleotidase, enzymes have a key role in the control of purinergic neuromodulation and neurotransmission. Treatment of diabetic rats with either Viagra or vitamin E significantly improved the diabetic deviation in the above tested parameters. However, administration of the combination of both drugs restored most of these parmeters to near their normal levels. The present data showed that Viagra has a beneficial effect against diabetic brain oxidative stress and related vascular and neuronal complications and its synergistic combination with vitamin E may render it to have an additional potential concern in ameliorating some brain disorders induced by diabetes.
  A.M. Mohamed , F.Z. EL-Sharkawy , S.A.A. Ahmed , W.M. Aziz and O.A. Badary
  This study investigated the possible antidiabetic role and therapeutic crucial action of two medicinal plants namely Curcuma longa L. (Zingiberaceae) rhizome and Nigella sativa L. (Ranunculaceae) seeds compared to the currently available antidiabetic drug gliclazide (diamicron) against diabetic complication induced liver injury in rats. Experimental diabetes was induced by a single-dose (40 mg kgG1, intraperitoneally, i.p.) streptozotocin (STZ)-injection and the two studied plants were administered orally (300 mg kgG1 b.wt. either each alone or in their synergistic combination) for 30 days commenced 2 weeks after induction of diabetes. The following parameters were measured: blood glucose (marker of hyperglycemia), blood fructosamine, hemoglobin (Hb) and albumin (indices of diabetic protein glycation), hepatic glycolytic enzymes, hexokinase (HK), pyruvate kinase (PK) and lactate dehdrogenase (LDH) as well as hepatic gluconeogenic enzyme, phophoenolpyruvate carboxykinase (PEPCK) (to assess the mechanism (s) of hypoglycemic action of the used plants), hepatic oxidative stress markers, Nitric Oxide (NO) and malondialdehyde (MDA, marker of lipid peroxidation), hepatic antioxidant markers including superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and reduced glutathione (GSH). Blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also measured as markers of liver function. The results revealed that induction of diabetes induces metabolic disorder and oxidative hepatopathy indicated by the deviation in the above markers in both blood and livers of diabetic rats. Oral administration of either C. longa rhizome or N. sativa seeds or their synergistic combination successfully modulated the diabetic increase in blood glucose and fructosamine to their normal levels as well as the consequence diabetic decrease in the Hb and albumin levels, indicating their potential antidiabetic and antiglycating abilities. The plants also effectively have beneficial action in up-regulating of hepatic glycolytic enzymes and down regulating the gluconeogenic enzyme which have the major role in diabetic hyperglycemia and this may demonstrate the mechanisms of glycemic control of these plants. Furthermore, ingestion of the current plants effectively modulated hepatic oxidative tissue damage indicated by amelioration of the deterioration occurred in oxidative stress and antioxidants markers in hepatic of diabetic animals and ensured by normalization of liver function blood enzymes activities, confirming their potential antioxidant activity. Supplementation of diabetic animals with gliclazide modulated diabetic induced alteration in most of the above studied markers. These results suggest that either C. longa rhizome or N. sativa seeds or their synergistic combination have multi-beneficial actions in controlling diabetes and consequence complication induced in liver and may candidate as natural antidiabetic drugs.
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