Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by A.M. Umarudeen
Total Records ( 2 ) for A.M. Umarudeen
  E.U. Etuk , A.M. Umarudeen , P.A. Onyeyili and A.T. Elsa
  A comparative plasma kinetics of sulphadimidine (100 mg kg-1, intravenous) studied by chemical assay in non-starved and starved rabbits has shown that; the mean peak plasma concentrations of the drug (101.70±5.74 μg mL-1) was higher in the starved than the non-starved animals (72.45±6.22 μg mL-1). The volume of distribution of the drug (Vdβ) and the total body clearance (CL) were significantly reduced after deprivation of food for 48 h in the animals. Equally, the elimination rate constant (β = 0.078 h-1) was higher in the non-starved than in the starved rabbits (β = 0.052 h-1). The study therefore concludes that, short term starvation has significantly increased the plasma concentrations and altered the kinetic profile of sulphadimidine following intravenous administration in rabbits. Thus, this factor should be considered when administering the drug to avoid dose dependent toxicity.
  E.U. Etuk , A.M. Umarudeen , P.A. Onyeyili and A.T. Elsa
  The tissue concentrations and kinetics of sulphadimidine (100 mg kg-1; intravenous) has been studied in normal and starved rabbits by chemical assay method. The results indicate that, different concentrations of the drug were obtained in the various tissues (liver, heart, kidney brain and skeletal muscle) examined. The drug persisted in the brain and skeletal muscle of the animals up to 12 days after its administration. The starved rabbits maintained consistently higher concentrations of the drug in its tissues as compared to the fed ones. The half-life of the drug was shortest in the liver (5.63 and 6.11 h) of the non-starved and starved rabbits, respectively. The elimination rate constants were correspondingly higher in the liver (0.210 and 0.230 h), respectively for the non-starved and starved rabbits. The study therefore concludes that, acute starvation can raise the tissue concentrations of sulphadimidine in rabbits and the safe withdrawal time following the administration of the drug should be in excess of twelve days.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility