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Articles by A.M. Homeida
Total Records ( 9 ) for A.M. Homeida
  M.H. Al-Nazawi and A.M. Homeida
  Intravenous administration of sulphadimidine (SDM) at a dose of 50 mg kg-1 body weight as a single-dose or repeated-dose treatments to lactating camels resulted in residues of SDM and its metabolite N4-acetyl in milk. Milking twice daily resulted in depletion of SDM and N4-acetyl residue during a withdrawal period of 5 days after the last injection of the drug. Milk protein binding and concentration of metabolite was very low suggesting that monitoring of sulphonamide residues in milk could be limited to SDM alone.
  Samia A.A. Hassan , Sania A.I. Shaddad , I.B. El-Tayeb , M.A. Omer , M.H. Al-Nazawi and A.M. Homeida
  Twelve healthy desert sheep were injected intramuscularly (IM) with multiple doses of 5 g kg-1 oxytetracycline (OTC) for detection of OTC residues in different tissues (Liver, kidney, muscle and site of injection). The animals were slaughtered and the tissue samples were collected from each sheep at times 1, 3, 7 and 10 days after drug administration. Samples were processed using microbiological method. The inhibition zone diameters were interpreted with oxytetracycline standard curve to obtain tissue concentrations. Oxytetracycline concentrations were evaluated in tissue at different times. High concentration were noted in liver (105±10.91 μg g-1) at day 1, kidney (234.93±10.57 μg g-1) at day 3 and muscle (3084.20±227.10 μg g-1) at day 1, while the highest concentrations were observed at site of injection (5963±227.10 μg g-1) at day 1. Day 7 and 10 showed low concentration of OTC in the liver (2.51±0.1 μg g-1), kidney (6.70±0. 1 μg g-1) and muscle (70.86±0.6 μg g-1). This study indicates the presence of long acting OTC concentrations in various tissues after injection of the drug. Significant difference in concentrations of the drug in the various tissues studied was demonstrated.
  Samia A.A. Hassan , Sana A.I. Shaddad , A.K. Muddathir , I.B. El-Tayeb , A.O.M. Nour , M.H. Al-Nazawi and A.M. Homeida
  The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg 1 body weight to fifteen healthy desert sheep. The mean Cmax values of 74.813.22 g mL 1 was after 0.90.13 h, the mean distribution phase was 2.00.4 h and the apparent elimination half-life was 12623 h. The volume of distribution (Vd) was found to be 67.9334.88 L. The area under the curve (AUC0240) and the area under concentration-time curve (AUMC) were 2530.26203.3, 242522.248504.5 g/ml/h2, respectively. The total body clearance (cl ) was 373.6318.9 mL h 1 while the mean resident time (MRT) was 90.6113.8 h.
  A.M. Homeida and S.A. AL-Shami
  Feeding of urea-treated wheat straw to camels resulted in significantly increased concentration of plasma urea compared to their counterparts that fed straw only. P-aminohippuric acid, inulin and urea clearances and filtered urea were also significantly higher in animals fed urea treated straw than in animals fed straw. It is suggested that in camels fed straw, the renal urea spare could serve for ruminal recycling of urea to compensate for low nitrogen diet.
  M.E. Al-Bowait , S.E.M. Barakat , M.H. Al-Nazawi , M.E. Barri and A.M. Homeida
  The effects of feeding convulvulus arvensis (binweed) at 0.5 and 1g/rat were investigated. Binweed produced no clinical effects or gross lesions in rats. The plant caused decreased concentration of protein in liver homogenate and inhibited the activity of phase-1 but not phase-2 drug metabolizing enzymes. In view of binweed modulating effects on drug metabolizing enzymes, consumption of binweed by human and animal should be prohibited.
  A.I. Sana Shaddad , A.A. Samia Hassan , I.B. ElTayeb , M.A. Omer , A.O.M. Nour , M.H. Al-Nazawi and A.M. Homeida
  The pharmacokinetics of tylosin after intramuscular administration at a dose of 1g kg-1 body weight was studied in eleven healthy desert sheep. A peak level of tylosin Cmax of 1980.95 g mL 1 was achieved after tmax of 0,90.13 h and the mean distribution half-life (t1/2 ) was 20.3 h and the apparent elimination half-life (t1/2 ) was 72.29.3 h. The volume of distribution (Vd) was found to be 53.2993.907 L. The area under the curve (AUC240) of tylosin was calculated as being 1947.8177.8 g mL 1 and the Area Under Maximum Concentration Curve (AUMC) was 74285.45420.75 g/mL/h2. The total clearance (cl ) was 511.7207 l h 1 and the mean resident time was 30±9.83 h.
  Samia A.A. Hassan , Sania A.I. Shaddad , I.B. ElTayeb , M.A. Omer , M.H. Al-Nazawi and A.M. Homeida
  A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg-1 tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.785.83, 315.9773.07 and 3956645.59 g g-1 were detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 191852966.9 g g-1 were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.50.24 and 5.220.20 g g-1 were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.
  A.M. Ahmed , O.S.A. Mohamed , S.E.M. Barakat , M.H. Al-Nazawi and A.M. Homeida
  Daily intraperitoneal administration of d-amphetamine sulphate at a dose of 8 mg kg 1 body weight to rats during 6-15 days of gestation has resulted in significant effect on sensory and motor reflexes of their pups. These pups have shown increased righting and rotating reflexes and cliff avoidance activity. Significant increase in brain noradernaline, 5-hydroxytryptamine and decrease in monoamine oxidase activity was observed in these pups and their mothers compared to their control counterparts.
  A.M. Homeida and A.I. Al-Mubarak
  Administration of progesterone in form of intravaginal devices in she camel has produced a uniform plasma concentration of progesterone depending on the dose of the device. Subcutaneous implant and intramuscular injection of progesterone produced a non-uniform plasma concentration of the hormone, possibly because of the damage to injection site in the muscle as reflected in elevated plasma creatine kinase activity. This suggested that the intravaginal device administration maybe a better route to provide a constant concentrations of progesterone in camel.
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