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Articles by A.K. Singh
Total Records ( 7 ) for A.K. Singh
  Man Singh , A. Singh , R.S. Tripathi , R.K. Verma , M.M. Gupta , H.O. Mishra , H.P. Singh and A.K. Singh
  About 4 strains of kalmegh (Andrographis paniculata Nees.), CIMAP/AP-3, CIMAP/AP-10 and CIMAP/AH-89 and local check were evaluated at three population densities (74,074, 111,111 and 222,222 plants ha-1) for growth behavior, biomass and diterpenoid lactones production at the Central Institute of Medicinal and Aromatic Plants, Lucknow, India during July to November, 2004 and 2005. The strain CIMAP/AP-3 was found to possess desired agronomic traits viz., 60 cm plant height, 45 cm plant spread, 28 branches per plant and 60° branching angle from main shoot. The advantage in biomass and diterpenoid lactones (andrographolide and neo-andrographolide) production with CIMAP/AP-3 over other strains was 33.4-79.4 and 31.6-70.7%, respectively. Planting at a closer spacing of 30x15 cm accommodating 2,22,222 plants ha-1 produced maximum dry biomass and andrographolide and neoandrographolide yield under the subtropical climate of North India.
  Ruchi Sharma and A.K. Singh
  Problem statement: Recombinant-based approaches are mostly focused on genetic modification of allergens to produce molecules with reduced allergenic activity and conserved antigenicity, such as hypoallergens. Recombinant allergens represent promising tools for diagnosis and therapy of type I allergy. This approach was probably feasible with every allergen with known amino acid sequence. Approach: The primary aim of this study was to determine the consensus epitope from twenty homologous protein sequences of Ory S1 allergenic protein sequence from Oryza sativa (indica group) pollen. Molecular modeling calculations had been used to investigate the allergenic protein models for the epitope. Results: Oryza sativa (japonica), Phleum pratense, Poa pratensis, Holcus lanatus, Lolium perenne, Triticum aestivum, Dactylis glomerata and Zea mays were found more closely related (alignment score 1145-812) among all the homologs and investigated further. The major binding pocket comprised an area of 604.5 Å2 and 970 Å3 volume and another key binding pocket had 425.6 Ų area and 658.8 ų volume. The residues found in the key site included ile2, lys13, cys14, ser15, lys16, pro17, ala25, leu26, ile27, tyr40, his41, phe42, asp43, leu44, ser45, gly46, leu47, ala48, met49, ala50, asp55, leu58, arg59, ala61, gly62, ile63, ile64, asp65, gln67, phe68; corresponding to the allergen binding site and the IgE binding epitope given in the title. Conclusion: These are the functional sites on the allergenic proteins that can be mutated to develop hypoallergenic vaccine. These sites can be rationalized on the basis of simple arguments that lead to vaccine development, by predicting the structure of the allergenic epitopes and comparative analysis.
  A.K. Singh , R.K. Tiwari , D.R. Kanaujia , J.P. Pandey and P. Mishra
  The importance of prawn as one of the beneficial food items for man because of having easily digestive high protein and iron and a low fat content is well known. The river Ganga having diversified fish fauna is considered to be the back bone of capture fishery in India. The present study was conducted on the growth, maturation and breeding behavior of Ganga river prawn, Macrobrachium gangeticum in the middle stretch of river Ganga in and around Varanasi, India. Specimens, 65-205 mm in size, were recorded during May to October. Percentage of males was found dominant in the month of May whereas females in months, July to October. Maximum males were recorded in the size range of 166-205 mm. Prawns started breeding in May which continued till October.
  Usha Singh , D.K. Singhal and A.K. Singh
  Transient method is used to determine effective thermal diffusivity of vegetables/fruits in temperature range of 0 to 45°C. The effective thermal diffusivity is obtained by solution of one dimensional (1D) Fourier heat conduction equation applied to a cylinder. The temperature is recorded at a number of points along the radius with respect to time and no approximation to surface convective heat transfer is required. The fruits taken are cucurbits, Musa acuminate L. (ripe and raw) and Malus domestica L. Effective thermal diffusivity in 0 to 45°C temperature varies from 1.38x10-9 to 16.6x10-9 m2 sec-1 Cucumis sativus L., 14.2x10-9 to 98.7x10-9 m2 sec-1 Luffa acutangula L. and 2.27x10-9 to 49.7x10-9 Lagenaria siceraria L. theoretically. The similar trend has also been found for other samples. The theoretical and experimental results are in good agreement.
  A.K. Singh , A.K. Verma , Neha , Ruchi Tiwari , K. Karthik , Kuldeep Dhama and S.V. Singh
  By 2050 to feed the estimated human population of around 9 billion, there is requirement of 50% increase the food production, which can only be fulfilled by clean, healthy and sustainable food animal production. Livestock industry is facing considerable economic losses due to infectious diseases. So an effective control strategy is need of today to control these infectious diseases and contribute in augmentation of livestock production. Parasitic diseases have a major impact on livestock production, reproduction and hence economy. Protozoan parasites are major causes of human and animal disease causing extensive morbidity and mortality, particularly parasitic disease in tropical and sub-tropical climatic regions. Many protozoal parasitic diseases are zoonotic. Limiting the impact of parasitism in both man and livestock relies almost exclusively on the use of antiparasitic drugs. Development of resistance towards chemotherapeutic agents has forced the scientist to discover some alternative for control of parasitic diseases. Recent advances in immunology and biotechnology have sensitized the scientists or researchers to develop the newer and safer vaccines for control of parasitic diseases. This review is intended to provide state-of-art information to the reader with an overview on the trends, advances and perspectives in vaccines and vaccinology against important parasitic diseases of livestock and poultry viz., coccidiosis, anaplasmosis, giardiosis, babesiosis, Neospora infection, toxoplasmosis, theleriosis, sarcocyst infestation, leishmaniasis, trypanosomiasis and trichomoniasis, which altogether play crucial role in the prevention of protozoan parasitic diseases of animals.
  Supriya Gupta , K.P. Singh and A.K. Singh
  Mango (Mangifera indica L.) production is drastically reduced by Colletotrichum gleosporoides, is one of the most damaging pathogen causing mango anthracnose. In order to find sources of resistance to this disease, forty mango cultivars were screened under natural epiphytotic conditions in horticulture research centre at Pantnagar for the last two years (viz., 2013 and 2014). Grouping of cultivars for disease intensity, infection rate and AUDPC showed that 5% cultivars were resistant, 30% moderately resistant, 22.5% moderately susceptible and remaining 42.5% susceptible to highly susceptible. Nariayal and Chenna Swarnarekha exhibited the minimum infection rate (0.018, 0.036) and AUDPC (427.98, 476.75) resulting in 16.67 and 19.17% disease intensity. Nine were moderately susceptible while rest of the cultivars were either susceptible or highly susceptible. Bada Malda cultivar showed the highest AUDPC (3294.14%) and the maximum percent disease intensity (92.34%). Other cultivars, however, exhibited intermediate range of infection rate and AUDPC. The disease progress curves clearly depicted the levels of disease in each cultivars during the observational periods. These resistant to moderately resistant mango cultivars can be used in breeding programme for developing varieties adapted to the region against anthracnose blight.
  K. Gill , A.K. Singh , S. Kumar , B. Mishra , V. Kapoor , S.N. Das , R.K. Somvanshi and S. Dey
  Ginger has been used in traditional Indian and Chinese medicine and is effective for a wide range of ailments including diarrhea, respiratory disorders, inflammatory diseases, arthritis etc. Recent studies have shown the role of ginger extract in the modulation of biochemical pathways involved in chronic inflammation and have thus provided evidences for its anti-inflammatory property. The aim of the study was to identify and purify a novel protein from ginger rhizomes (Zingiber officinales), of Zingiberaceae family possessing anti-fungal, anti-inflammatory and anti-proliferative properties as elicited using antibiotic diffusion method, surface plasmon resonance, spectrophotometric analysis and flow cytometry, respectively. The purified protein G-24 having molecular mass of 24 kD exhibited a potent anti-fungal activity against the mycelial growth in Fusarium exysporum and Candida albicans. It had shown 60% inhibition of human oral cancer cell line (KB cells) at 10 μM concentration. It inhibited inflammatory enzymes; lipooxygenase (LOX) and cyclooxygenase-2 (COX-2) with KD values of 2.04 μM and 2.74 nM, respectively. This confirmed the anti-inflammatory property of G-24.Thus, concluded that the G-24 protein possessed multiple functions viz. antifungal, anti-inflammation and antiproliferation.
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