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Articles by A.K. Nisha
Total Records ( 2 ) for A.K. Nisha
  A.K. Nisha , S. Meignanalakshmi and K. Ramasamy
  Cyclosporin aids in the differentiation and proliferation of T-cytotoxic lymphocytes that are the main cause of the rejection of organ transplantations. Fungi belonging to the Class Deuteromycetes, Tolypocladium inflatum (ATCC 34921) in submerged fermentations, accomplish the production of cyclosporin. In this study, a comparison was made in the yields of cyclosporin in both the solid and submerged fermentations (SmF) with and without the addition of amino acids. A 40% increased yield in cyclosporin was obtained with SSF when compared to the SmF without the addition of amino acids. Though the incubation periods were higher in SSF, an increased yield was achieved with the addition of L-valine (221.6 mg kg-1),L-leucine (206.4 mg kg-1) and L-α-Aminobutyric acid (204.9mgkg-1).
  A.K. Nisha and K. Ramasamy
  Cyclosporins are widely produced through submerged fermentations. Solid state fermentation has been used successfully for the production of enzymes and secondary metabolites. Use of different solid substrate medium for the growth and production of cyclosporin by Tolypocladium inflatum (ATCC 34921) was carried out to increase the cyclosporin yield and to economize the process of production using solid state fermentation. Locally available and cheaper materials like rice bran, wheat bran, rice husk, wheat husk, rice grit, wheat grit, gingili cake, cottonseed cake, groundnut cake, coconut cake and sunflower cake were used. Among the solid substrates included in the study, wheat bran was found to be supportive both in terms of biomass (22 g kg-1) and cyclosporin production (179 mg kg-1).
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