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Articles by A.K. Gupta
Total Records ( 6 ) for A.K. Gupta
  Pranati , Sanjiva Bimal , K. Pandey , P.K. Sinha , A.K. Gupta , Shubhankar K. Singh , Shanthy Sundaram and P. Das
  Cytokine behavior of T-lymphocytes is not very clear when a patient is co-infected with Leishmania donovani and HIV. To achieve this we studied groups of patients comprising of VL infected, HIV infected and HIV-VL co-infected cases. As compared to lone infections by either of the infecting agent, the co-infection cases showed greatly diminished CD4 T-cell counts and slightly enhanced values of cytokines (IFNγ and IL4). The effect of 63 KDa antigenic fraction of L. donovani, previously reported by our group as having potential immunoprophylaxis effects, was also studied for its effect on T-cell cytokine pattern in the co-infection cases. It was interesting to find that this antigenic fraction showed an increase in the proportion of CD4 T-cells secreting IFNγ in both VL (alone) and HIV-VL co-infection groups.
  V. Vijayan and A.K. Gupta
  Results are presented from successfully designed and fabricated meso-scale ceramic combustors that incorporate internal thermal energy recirculation. The combustor provided sustained operation using propane and air as the reactants. Flames could be obtained well below the normal quenching distance. The development required examination of several different combustor designs and materials. Flammability limits of these combustors have been determined experimentally. Experimental investigations have been performed on the effects of flame holder geometry, material conductivity, equivalence ratio, and inlet Reynolds number on the combustor performance. Measurement of the reactant preheating and product exhaust temperatures was performed using K-type thermocouples which were installed with minimal intrusion to the flow. The reactant preheating temperatures were observed to be in the range 700 K-1000 K. However, the combustor suffered significant overall heat loss (50-85%) which was implied by the low exhaust temperatures (500 K-750 K). For a constant fuel flow rate, the exhaust temperature increased monotonously with decrease in equivalence ratio until the blow-off condition implying that the combustor’s maximum thermal efficiency occurs at its lean blow-off limit. Thermal imaging of the combustor walls was performed using infrared camera to obtain the temperature distribution within the combustor. Numerical simulations were performed with the aid of CFD software using a heat loss coefficient chosen so as to give best correlation with experimental results. These CFD simulations helped to obtain better insight of the dependence of combustor performance on thermal conductivity of the material and heat load.
  V. Vijayan and A.K. Gupta
  The dynamics of premixed propane-air flame in a meso-scale ceramic combustor has been examined here. The flame characteristics in the combustor were examined by measuring the acoustic emissions and preheat temperatures together with high-speed cinematography. For the small-scale combustor, the volume to surface area ratio is small and hence the walls have significant effect on the global flame structure, flame location and flame dynamics. In addition to the flame-wall thermal coupling there is a coupling between flame and acoustics in the case of confined flames. Flame-wall thermal interactions lead to low frequency flame fluctuations (not, vert, similar100 Hz) depending upon the thermal response of the wall. However, the flame-acoustic interactions can result in a wide range of flame fluctuations ranging from few hundred Hz to few kHz. Wall temperature distribution is one of the factors that control the amount of reactant preheating which in turn effects the location of flame stabilization. Acoustic emission signals and high-speed flame imaging confirmed that for the present case flame-acoustic interactions have more significant effect on flame dynamics. Based on the acoustic emissions, five different flame regimes have been identified; whistling/harmonic mode, rich instability mode, lean instability mode, silent mode and pulsating flame mode.
  Anuradha Bhardwaj , Varij Nayan , Parvati , Mamta and A.K. Gupta
  Inhibin is a non-steroidal glycoprotein hormone of gonadal origin with major action as negative feedback control of the production of Follicle Stimulating Hormone (FSH) by anterior pituitary gland which in turn modulates male and female reproductive functions. Its physiological role has led to the development of inhibin based immunogens for fertility enhancement in farm animals. It is envisaged that a reduction of endogenous inhibin secretion would increase FSH concentrations and thus offers a potential for increasing the number of ovulatory follicles in the ovary. Immunization against inhibin has been reported to be a useful method for inducing multiple ovulations in farm animals. Inhibins play important roles in the regulation of fertility based on their dual inhibitory action on the process of folliculogenesis in the ovary and FSH secretion by the pituitary. Inhibins are also recognized as paracrine ovarian and testicular regulators and have multiple paracrine effects in the utero-placental unit, representing a promising marker for male and female infertility, gynecological and gestational diseases.
  D. Jeena , M. Baunthiyal , D. Pandey and A.K. Gupta
  Mitogen-Activated Protein (MAP) kinases play very important role in signal transduction during pathogen attack. We attempted to study the response of MAPK4 and MAPK6 under three different conditions i.e., with pathogen (Alternaria brassicae) only, with zeatin only and with both pathogen and zeatin. The study was performed on Arabidopsis thaliana (A. thaliana) plants. The objective was to identify the relationship between zeatin and disease resistance. To our surprise, we found an increased disease incidence in presence of pathogen at middle stage along with zeatin and also observed increased expression of MAPK4 under similar condition. MAPK6 expressions are already known to be increased during the disease incidence and in our case it has increased expression during the application of both pathogen as well as zeatin. Two-dimensional (2D) analysis of these samples revealed that the upregulated proteins were mostly in the range of 35-50 kDa range which is similar to the range of where all the MAP kinases.
  Saurabh Singh , Bijendra Kumar Singh , S.M. Yadav and A.K. Gupta
  Agriculture provides food for humans, directly and indirectly. As world population is increasing, it is necessary to use the modern technologies such as bio and nanotechnologies in agricultural sciences. Nanotechnology has been defined as relating to materials, systems and processes which operate at a scale of 100 nm or less. Nanotechnology has many applications in all stages of production, processing, storing, packaging and transport of agricultural products. Nanotechnology will revolutionize agriculture and food industry by innovation new techniques such as: Precision farming techniques, enhancing the ability of plants to absorb nutrients, more efficient and targeted use of inputs, disease detection and control diseases, withstand environmental pressures and effective systems for processing, storage and packaging.
 
 
 
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