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The aim of present study was to investigate the potential roles of aqueous
extracts of A. paniculate in lowering the plasama lipid parameter which
is responsible for hyperlipidemia and its damaging consequences and also to
determine the kidney and liver functions of rats. Plasma Total Cholesterol (TC),
Low Density Lipoproteins (LDL) cholesterol and Triglycerides (TG) had
progressively increased in cholesterol-fed rats up to 4 weeks of
cholesterol-feeding. Both 100 and 200 mg kg 1 concentrations of A.
paniculata extracts had kept TC, LDL and TG values within the normal range
even after 4 weeks of feeding. No significant enhancement was found in the
amount of High Density Lipoproteins (HDL) cholesterol and the kidney and liver
enzymes of the rats, i.e. Blood Urea Nitrogen (BUN), total creatinine and
Lactate Dehydrogenase (LDH) and Aspartate Amino Transferase (AST) and Alanine
Aminotransferase (ALT), respectively indicating normal kidney and liver
functions. From the current study, it can be concluded that 100 and 200 mg
kg 1 aqueous extract of A. paniculata appeared to possess
great potentials as anti-hyperlipidemic agent in rats.
